CTBP1 anticorps (AA 425-440)

N° du produit ABIN3030237

Détail du produit anti-CTBP1 anticorps

Antigène: CTBP1 (C-terminal Binding Protein 1 (CTBP1))

Épitope: AA 425-440

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CTBP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogène: Amino acids 425-440 (QTVKPEADRDHASDQL-human) were used as the immunogen for this CtBP1 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the CtBP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the CtBP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur CTBP1

Antigène: CTBP1 (C-terminal Binding Protein 1 (CTBP1))

Autre désignation: CtBP1 (CTBP1 Produits)

Synonymes: anticorps BARS, anticorps CtBP1-L, anticorps CtBP1-S, anticorps CtBP3/BARS, anticorps D4S115h, anticorps D5H4S115, anticorps D5H4S115E, anticorps 50-kDaBFA-inducedADP-ribosylatedsubstrate, anticorps BARS-50, anticorps Bars, anticorps wu:fi43a11, anticorps CtBP, anticorps ctbp1-A, anticorps xctbp1, anticorps bars, anticorps CTBP1, anticorps C-terminal binding protein 1, anticorps C-terminal binding protein 1 L homeolog, anticorps CTBP1, anticorps Ctbp1, anticorps ctbp1, anticorps ctbp1.L

Sujet: C-terminal-binding protein 1 is encoded by the CTBP1 gene. It binds to the C-terminus of adenovirus E1A proteins. It is a transcriptional repressor(corepressor) and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. CtBP1 and CtBP2 preferentially associate with the E1A via a 5 amino acid motif, PLDLS, to repress E1A induced oncogenesis and cellular transformation. CtBP1 is expressed from embryo to adult, but CtBP2 is mainly expressed during embryogenesis. During skeletal and T cell development, CtBP1 and -2 associate with the PLDLSL domain of delta EF1, a cellular zinc finger-homeodomain protein, and thereby enhances delta EF1-induced transcriptional silencing. In addition, CtBP complexes with CtIP, a 125 kDa protein that recognizes distinctly different protein motifs from CtBP. CtIP binds to the BRCT repeats within the breast cancer gene BRCA1 and enables CtBP to influence BRCA1 activity. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.

UniProt: Q13363

Pathways: Retinoic Acid Receptor Signaling Pathway