GRIA2 anticorps (AA 25-360)

N° du produit ABIN3031067

Il existe 1 publication pour ce produit. L’anticorps anti-GRIA2 Polyclonal Lapin est utilisé pour la détection de GRIA2 dans des échantillons de Humain, Rat et Souris. Il a été validé pour WB, IF, FACS et IHC (p).

Aperçu rapide pour GRIA2 anticorps (AA 25-360) (ABIN3031067)

Antigène: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRIA2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-GRIA2 anticorps

Épitope: AA 25-360

Fonction: GLUR2 Antibody / Glutamate Receptor 2 / GRIA2

Purification: Antigen affinity

Immunogène: Human partial recombinant protein (AA 25-360) was used as the immunogen for this GLUR2 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the GLUR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the GLUR2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Références pour anticorps anti-GRIA2 (ABIN3031067)

Liu, Woo, Bukhari, Wang, Yan, Buosi, Ermekbaeva, Sista, Kotsiviras, LePochat, Chacko, Zhao, Kang: "Modulation of synaptic plasticity, motor unit physiology, and TDP-43 pathology by CHCHD10." dans: Acta neuropathologica communications, Vol. 10, Issue 1, pp. 95, (2022) (PubMed).

Détails sur GRIA2

Antigène: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Autre désignation: GLUR2

Sujet: Glutamate receptor 2, also known as GLUR2, is a protein that in humans is encoded by the GRIA2 gene. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. The crystal structures of the GLUR2 ligand-binding core in the apo state and in the presence of the antagonist DNQX, the partial agonist kainate, and the full agonists AMPA and glutamate. GLUR2 plays a major role in depression at synapses in which glutamate remains in the synaptic cleft for prolonged periods of time during normal operation of the synapse. Overexpression increases dendritic spine size and density in hippocampal neurons, and more remarkably, induces spine formation in GABA-releasing interneurons that normally lack spines.

UniProt: P42262

Pathways: Signalisation PI3K-Akt