Merlin anticorps (pSer518)

N° du produit ABIN303117

Cet anticorps anti-Merlin Polyclonal Lapin (ABIN303117) détecte spécifiquement Merlin dans WB, IP, IHC (p) et EIA. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour Merlin anticorps (pSer518) (ABIN303117)

Antigène: Merlin (NF2) (Neurofibromin 2 (NF2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Merlin est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-Merlin anticorps

Épitope: pSer518

Specificité: This antibody is specific for the phosphorylated form of Human NF2 (Merlin).

Réactivité croisée (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Human

Purification: Immunoaffinity Chromatography.

Immunogène: Human NF2 (Merlin) phospho-peptide corresponding to a region of the human protein surrounding S518 and conjugated to Keyhole Limpet Hemocyanin (KLH).

Information d'application

Indications d'application: ELISA. Western Blot. Immunoprecipitation. Immunohistochemistry on Paraffin Sections (2.5 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2 with 0.01 % (w/v) Sodium Azide as preserevative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to immediate use.

Détails sur Merlin

Antigène: Merlin (NF2) (Neurofibromin 2 (NF2))

Autre désignation: Merlin

Sujet: The recently isolated neurofibromatosis 2 tumor suppressor gene encodes a 595 amino acid protein (Merlin). The protein product Merlin, named for its relatedness to the ezrin, radixin and moesin (ERM) family of proteins, is a tumor suppressor whose absence results in the occurrence of multiple tumors of the nervous system, particularly schwannomas and meningiomas. Merlin's similarity to ERMs suggests that it might share functions, acting as a link between cytoskeletal components and the cell membrane. The NF2 protein is highly expressed in human fibroblasts and is detected as a single band of about 75 kDa.Synonyms: Moesin-ezrin-radixin-like protein, NF2, Neurofibromin-2, SCH, Schwannomerlin, Schwannomerlin, Schwannomin, Schwannomin

ID gène: 4771

NCBI Accession: NP_000259

UniProt: P35240

Pathways: Cell-Cell Junction Organization