Huntingtin anticorps (C-Term)

N° du produit ABIN3031257

Cet anticorps anti-Huntingtin est un anticorps Polyclonal produit chez le Lapin, détectant Huntingtin dans WB. Convient pour Humain, Rat et Souris.

Aperçu rapide pour Huntingtin anticorps (C-Term) (ABIN3031257)

Antigène: Huntingtin (HTT)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Huntingtin est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Huntingtin anticorps

Épitope: C-Term

Purification: Antigen affinity

Immunogène: An amino acid sequence from the C-terminus of human HTT (ELDRRAFQSVLEVVAA) was used as the immunogen for this Huntingtin antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the Huntingtin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the Huntingtin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur Huntingtin

Antigène: Huntingtin (HTT)

Autre désignation: Huntingtin

Sujet: The Huntingtin gene, also called HTT or HD (Huntington disease), is the IT15 (interesting transcript 15) gene which codes for a protein called the Huntingtin. The protein has no sequence homology with other proteins and is highly expressed in neurons and tests in humans and rodents. HTT upregulates the expression of Brain Derived Neurotrophic Factor (BDNF) at the transcription level, and this gene is required for normal development. HTT is involved in vesicle trafficking as it interacts with HIP1, a clathrin-binding protein, to mediate endocytosis, the absorption of materials into a cell. HTT was also visualized as punctate staining likely to represent nerve endings. Additionally, wildtype Huntingtin may function in the nucleus in the assembly of nuclear matrix-bound protein complexes involved with transcriptional repression and RNA processing.

UniProt: P42858

Pathways: Signalisation PI3K-Akt, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport