IL-17 anticorps (AA 26-158)

N° du produit ABIN3031457

Détail du produit anti-IL-17 anticorps

Antigène: IL-17 (IL17) (Interleukin 17 (IL17))

Épitope: AA 26-158

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL-17 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antigen affinity

Immunogène: Mouse partial recombinant protein (AA 26-158) was used as the immunogen for this IL17 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the IL17 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,ELISA: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the IL17 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur IL-17

Antigène: IL-17 (IL17) (Interleukin 17 (IL17))

Autre désignation: IL17 (IL17 Produits)

Synonymes: anticorps CTLA8, anticorps IL-17, anticorps IL-17A, anticorps IL17, anticorps Ctla-8, anticorps Ctla8, anticorps Il17, anticorps ChIL-17, anticorps IL-17F, anticorps IL17A, anticorps CTLA-8, anticorps interleukin 17A, anticorps IL17A, anticorps Il17a

Sujet: IL-17(Interleukin-17), originally identified as a transcript from a rodent T-cell hybridoma by Rouvier et al. in 1993, is the founding member of a group of cytokines called the IL-17 family. Known as CTLA8 in rodents, IL-17 shows high homology to viral IL-17 encoded by an open reading frame of the T-lymphotropic rhadinovirus Herpesvirus saimiri. Mouse IL-17 shares 85 % amino acid sequence homology with rat. Interleukin 17 is a cytokine that acts as a potent mediator in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to Interferon gamma. IL-17 is produced by T-helper cells and is induced by IL-23 which results in destructive tissue damage in delayed-type reactions. Interleukin 17 as a family functions as a proinflammatory cytokine that responds to the invasion of the immune system by extracellular pathogens and induces destruction of the pathogen's cellular matrix. Interleukin 17 acts synergistically with tumor necrosis factor and interleukin-1. To elicit its functions, IL-17 binds to a type I cell surface receptor called IL-17R of which there are at least three variants IL17RA, IL17RB, and IL17RC.

UniProt: Q62386