Netrin 1 anticorps (AA 32-51)

N° du produit ABIN3031963

Détail du produit anti-Netrin 1 anticorps

Antigène: Netrin 1 (NTN1)

Épitope: AA 32-51

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Netrin 1 est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: Amino acids 32-51 (AGQAAQPDPCSDENGHPRRC) were used as the immunogen for this Netrin 1 antibody (100% homologous in human, mouse and rat).

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the Netrin 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the Netrin 1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur Netrin 1

Antigène: Netrin 1 (NTN1)

Autre désignation: Netrin 1 (NTN1 Produits)

Synonymes: anticorps ntn1-A, anticorps Netrin-1, anticorps NTN1, anticorps unc-6, anticorps MGC147073, anticorps NTN1L, anticorps AI561871, anticorps BC019633, anticorps netrin-1, anticorps netrin 1 L homeolog, anticorps netrin 1, anticorps ntn1.L, anticorps NTN1, anticorps ntn1, anticorps Ntn1

Sujet: Netrin-1 (NTN1), also known as NTN1L, is a diffusible protein made by floor plate cells. It is found in the floor plate and neuroepithelial cells of the ventral region of the spinal cord, as well as other locations in the nervous system including the somatic mesoderm, pancreas and cardiac muscle. The human NTN1 gene is mapped to chromosome 17p13-p12 by FISH. Netrin-1 can attract spinal commissural axons and repel trochlear axons in vitro. And expression confers a selective advantage for tumor cell survival. The binding of netrin-1 to DCC appears to depend on the presence of a coreceptor or accessory proteins. Adenosine A2b receptor is actually its receptor and induces cAMP accumulation on binding netrin-1, and that dependent outgrowth of dorsal spinal cord axons directly involves A2b. Netrin-1 can promote intestinal tumor development, probably by regulating cell survival. Thus, a receptor or receptors function as conditional tumor suppressors.

UniProt: O95631

Pathways: Regulation of Cell Size