NUMB anticorps (AA 194-220)

N° du produit ABIN3032081

Détail du produit anti-NUMB anticorps

Antigène: NUMB (Numb Homolog (NUMB))

Épitope: AA 194-220

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NUMB est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: Amino acids 194-220 (SFRVTTATEQAEREEIMKQMQDAKKAE-human) were used as the immunogen for this Numb antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the Numb antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the Numb antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur NUMB

Antigène: NUMB (Numb Homolog (NUMB))

Autre désignation: Numb (NUMB Produits)

Synonymes: anticorps C14orf41, anticorps S171, anticorps c14_5527, anticorps Nb, anticorps NUMB, endocytic adaptor protein, anticorps numb homolog (Drosophila), anticorps NUMB, anticorps Numb, anticorps numb

Sujet: Numb is a protein that in humans is encoded by the gene of the same name. The encoded protein, whose degradation is induced in a proteasome-dependent manner by < a href=../search_result.php?search_txt=mdm>MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. The primary function of Numb in cell differentiation is as an inhibitor of < a href=../search_result.php?search_txt=notch>Notch signaling which is essential for maintaining self-renewal potential in stem and progenitor cells. Numb also plays a crucial role in asymmetrical cell division during development, allowing for differential cell fate specification in the central and peripheral nervous systems. Additionally, the protein product controls binary cell fate decisions in the peripheral and central nervous systems of both invertebrates and mammals during neurogenesis.

ID gène: 8650

Pathways: Cell-Cell Junction Organization