PROC anticorps (AA 446-461)

N° du produit ABIN3032367

Détail du produit anti-PROC anticorps

Antigène: PROC (Vitamin K-dependent protein C (PROC))

Épitope: AA 446-461

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PROC est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogène: Amino acids 446-461 (HGHIRDKEAPQKSWAP) were used as the immunogen for this Protein C antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the Protein C antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the Protein C antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur PROC

Antigène: PROC (Vitamin K-dependent protein C (PROC))

Autre désignation: Protein C (PROC Produits)

Synonymes: anticorps proc, anticorps si:ch1073-188c16.3, anticorps zgc:63987, anticorps PROC, anticorps APC, anticorps PC, anticorps PROC1, anticorps THPH3, anticorps THPH4, anticorps proc1, anticorps MGC64425, anticorps PA, anticorps protein C, inactivator of coagulation factors Va and VIIIa, anticorps protein C (inactivator of coagulation factors Va and VIIIa), a, anticorps protein C (inactivator of coagulation factors Va and VIIIa), anticorps protein C, inactivator of coagulation factors Va and VIIIa S homeolog, anticorps vitamin K-dependent protein C, anticorps prosaposin, anticorps protein C, anticorps proline rich protein HaeIII subfamily 1, anticorps PROC, anticorps proca, anticorps proc.S, anticorps proc, anticorps CpipJ_CPIJ000393, anticorps CpipJ_CPIJ002754, anticorps CpipJ_CPIJ003717, anticorps CpipJ_CPIJ003718, anticorps CpipJ_CPIJ014440, anticorps CpipJ_CPIJ018032, anticorps CpipJ_CPIJ018737, anticorps PSAP, anticorps Proc, anticorps PRH1

Classe de substances: Viral Protein

Sujet: Protein C (PROC), also called PC, is a zymogenic (inactive) protein, the activated form of which plays an important role in regulating blood clotting, inflammation, cell death and maintaining the permeability of blood vessel walls in humans and other animals. The PROC gene is mapped on 2q14.3. The PROC gene contains 8 exons and spans about 11 kb by Foster et al. The conversion of Protein C to a protease with anticoagulant function by thrombin requires as a cofactor thrombomodulin, an endothelial cell membrane protein. Riewald et al. demonstrated that activated Protein C uses the endothelial cell protein C receptor as a coreceptor for cleavage of protease-activated receptor-1 on endothelial cells. Faust et al. demonstrated that the endothelial pathways required for Protein C activation are impaired in severe meningococcal sepsis. They stated that improvement in the outcome of children with meningococcal sepsis who were treated with unactivated Protein C concentrates had been described in case reports and in one uncontrolled series.

UniProt: P04070