MFN2 anticorps (AA 601-757)

N° du produit ABIN3042362

Détail du produit anti-MFN2 anticorps

Antigène: MFN2 (Mitofusin 2 (MFN2))

Épitope: AA 601-757

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MFN2 est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for Mitofusin-2(MFN2) detection. Tested with WB in Human.

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Mitofusin-2(MFN2) detection. Tested with WB in Human.
Gene Name: mitofusin 2
Protein Name: Mitofusin-2

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Mitofusin 2 recombinant protein (Position: V601-R757). Human Mitofusin 2 shares 96% and 95% amino acid (aa) sequence identity with mouse and rat Mitofusin 2, respectively.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for Mitofusin 2 is approximately 0.25 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-MFN2 (ABIN3042362)

Montaigne, Marechal, Coisne, Debry, Modine, Fayad, Potelle, El Arid, Mouton, Sebti, Duez, Preau, Remy-Jouet, Zerimech, Koussa, Richard, Neviere, Edme, Lefebvre, Staels: "Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients." dans: Circulation, Vol. 130, Issue 7, pp. 554-64, (2014) (PubMed).

Détails sur MFN2

Antigène: MFN2 (Mitofusin 2 (MFN2))

Autre désignation: MFN2 (MFN2 Produits)

Synonymes: anticorps CG3869, anticorps Dmel\\CG3869, anticorps MARF, anticorps Marf-1, anticorps Mfn, anticorps anon-WO0125274.3, anticorps dMFN, anticorps dMfn, anticorps dmfn, anticorps marf, anticorps mfn, anticorps mfn2, anticorps MFN2, anticorps hsg, anticorps cmt2a, anticorps cprp1, anticorps cmt2a2, anticorps CMT2A, anticorps CMT2A2, anticorps CPRP1, anticorps HSG, anticorps D630023P19Rik, anticorps Fzo, anticorps mg:cb01g09, anticorps si:dkeyp-104h9.2, anticorps wu:fb79a11, anticorps mitofusin 2, anticorps Mitochondrial assembly regulatory factor, anticorps mitofusin-2, anticorps mitofusin 2 L homeolog, anticorps MFN2, anticorps Marf, anticorps mfn2, anticorps LOC100186475, anticorps Mfn2, anticorps mfn2.L

Sujet: Mitofusin-2 is a protein that in humans is encoded by the MFN2 gene. It is mapped to chromosome 1 and encodes a 757-amino acid protein that contains an ATP/GTP-binding site motif. This gene is expressed in many tissues and cell lines such as brain and KG-1 with the highest expression in heart and skeletal muscle. It has been found that MFN2 triggers mitochondrial energization, at least in part, by regulating OXPHOS expression through signals that are independent of its role as a mitochondrial fusion protein. And it contributes to the maintenance and operation of the mitochondrial network. Axonal CMT type 2A and autosomal dominant HMSN VI are caused by MFN2 and mutations in MFN2, which emphasizes its important role of mitochondrial function for both optic atrophies and peripheral neuropathies.

Synonyms: CMT2A antibody|CMT2A2 antibody|CPRP 1 antibody|CPRP1 antibody|Fzo antibody|HSG antibody|hyperplasia suppressor gene antibody|Hypertension related protein 1 antibody|KIAA0214 antibody|MARF antibody|MFN 2 antibody|Mfn2 antibody|MFN2_HUMAN antibody|Mitochondrial assembly regulatory factor antibody|Mitofusin-2 antibody|Mitofusin2 antibody|Transmembrane GTPase MFN2 antibody

ID gène: 9927

UniProt: O95140

Pathways: Skeletal Muscle Fiber Development