GRIK1 anticorps (AA 271-450)

N° du produit ABIN3042430

Cet anticorps Lapin Polyclonal détecte spécifiquement GRIK1 dans WB et IHC. Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour GRIK1 anticorps (AA 271-450) (ABIN3042430)

Antigène: GRIK1 (Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRIK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-GRIK1 anticorps

Épitope: AA 271-450

Fonction: Anti-GRIK1 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-GRIK1 Antibody Picoband® (ABIN3042430). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human GRIK1 recombinant protein (Position: R271-I450). Human GRIK1 shares 88% and 94% amino acid (aa) sequences identity with mouse and rat GRIK1, respectively.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
1. "Entrez Gene: GRIK1 glutamate receptor, ionotropic, kainate 1" 2. Eubanks, J. H., Puranam, R. S., Kleckner, N. W., Bettler, B., Heinemann, S. F., McNamara, J. O. The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis. Proc. Nat. Acad. Sci. 90: 178-182, 1993.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur GRIK1

Antigène: GRIK1 (Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1))

Autre désignation: GRIK1

Sujet:

Synonyms: Glutamate receptor ionotropic, kainate 1,GluK1,Excitatory amino acid receptor 3,EAA3,Glutamate receptor 5,GluR-5,GluR5,GRIK1,GLUR5,

Tissue Specificity: Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.

Background: Glutamate receptor, ionotropic, kainate 1, also known as GLUR5, is a protein that in humans is encoded by the GRIK1 gene. It is mapped to 21q21.3. This gene encodes one of the many ionotropic glutamate receptor (GluR) subunits that function as a ligand-gated ion channel. The specific GluR subunit encoded by this gene is of the kainate receptor subtype. Receptor assembly and intracellular trafficking of ionotropic glutamate receptors are regulated by RNA editing and alternative splicing. These receptors mediate excitatory neurotransmission and are critical for normal synaptic function. Exons of this gene are interspersed with exons from the C21or f41 gene, which is transcribed in the same orientation as this gene but does not seem to encode a protein.

Poids moléculaire: 104 kDa

ID gène: 2897

UniProt: P39086

Pathways: Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity