Thrombospondin 1 anticorps (N-Term)

N° du produit ABIN3042477

Cet anticorps anti-Thrombospondin 1 Polyclonal Lapin (ABIN3042477) détecte spécifiquement Thrombospondin 1 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Thrombospondin 1 anticorps (N-Term) (ABIN3042477)

Antigène: Thrombospondin 1 (THBS1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Thrombospondin 1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Thrombospondin 1 anticorps

Épitope: AA 58-86, N-Term

Fonction: Anti-Thrombospondin/THBS1 Antibody

Séquence: AFRIEDANLI PPVPDDKFQD LVDAVRAEK

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-Thrombospondin/THBS1 Antibody (ABIN3042477). Tested in WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human THBS1, different from the related mouse sequence by five amino acids.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Human

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur Thrombospondin 1

Antigène: Thrombospondin 1 (THBS1)

Autre désignation: THBS1

Sujet:

Synonyms: Thrombospondin-1,THBS1,TSP, TSP1,

Tissue Specificity: Mainly expressed in the brain and adrenal glands.

Background: THBS1 is also known as Thrombospondin 1, TSP1. The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. It is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Also this protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. In addition, the thrombospondin-1 protein is a member of the thrombospondinfamily. It is a multi-domain matrix glycoprotein that has been shown to be a natural inhibitor of neovascularization and tumorigenesis in healthy tissue. Both positive and negative modulation of endothelial cell adhesion, motility, and growth have been attributed to TSP1. This should not be surprising considering that TSP1 interacts with at least 12 cell adhesion receptors, including CD36, αv integrins, β1 integrins, syndecan, and integrin-associated protein (IAP or CD47). It also interacts with numerous proteases involved in angiogenesis, including plasminogen, urokinase, matrix metalloproteinase, thrombin, cathepsin, and elastase.

Sequence Similarities: Belongs to the thrombospondin family.

Poids moléculaire: 190 kDa

ID gène: 7057

UniProt: P07996

Pathways: Autophagy