Otoferlin anticorps (C-Term)

N° du produit ABIN3042499

Cet anticorps Lapin Polyclonal détecte spécifiquement Otoferlin dans IHC et WB. Il présente une réactivité envers Souris et Rat.

Aperçu rapide pour Otoferlin anticorps (C-Term) (ABIN3042499)

Antigène: Otoferlin (OTOF)

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Otoferlin est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Détail du produit anti-Otoferlin anticorps

Épitope: AA 1831-1863, C-Term

Fonction: Anti-Otoferlin Antibody

Séquence: QIWDADHFSA DDFLGAIELD LNRFPRGAKT AKQ

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-Otoferlin Antibody (ABIN3042499). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human Otoferlin, identical to the related mouse and rat sequences.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur Otoferlin

Antigène: Otoferlin (OTOF)

Autre désignation: OTOF

Sujet:

Synonyms: Otoferlin,Fer-1-like protein 2,OTOF,FER1L2,

Tissue Specificity: Isoform 1 and isoform 3 are found in adult brain. Isoform 2 is expressed in the fetus and in adult brain, heart, placenta, skeletal muscle and kidney.

Background: Otoferlin is a protein that in humans is encoded by the OTOF gene. Mutations in this gene are a cause of neurosensory nonsyndromic recessive deafness, DFNB9. The short form of the encoded protein has three C2 domains, a single carboxy-terminal transmembrane domain found also in the C. elegans spermatogenesis factor FER-1 and human dysferlin, while the long form has six C2 domains. The homology suggests that this protein may be involved in vesicle membrane fusion. Several transcript variants encoding multipleisoforms have been found for this gene.

Sequence Similarities: Belongs to the ferlin family.

Poids moléculaire: 227 kDa

ID gène: 9381

Pathways: Sensory Perception of Sound, Synaptic Vesicle Exocytosis