Interleukin 17a anticorps (AA 26-158)

N° du produit ABIN3042799

Cet anticorps Lapin Polyclonal détecte spécifiquement Interleukin 17a dans ELISA et WB. Il présente une réactivité envers Souris et a été mentionné dans 2+ publications.

Aperçu rapide pour Interleukin 17a anticorps (AA 26-158) (ABIN3042799)

Antigène: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Interleukin 17a est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-Interleukin 17a anticorps

Épitope: AA 26-158

Fonction: Anti-IL17/IL17A Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-IL17/IL17A Antibody (ABIN3042799). Tested in ELISA, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived mouse IL-17 recombinant protein (Position: A26-A158).

Isotype: IgG

Information d'application

Indications d'application: ELISA, 0.1-0.5 μg/mL, -
Western blot, 0.1-0.5 μg/mL, Mouse
1. Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., Weaver, C. T.Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.Nature Immun. 6: 1123-1132, 2005. 2. Kennedy, J., Rossi, D. L., Zurawski, S. M., Vega, F., Jr.Kastelein, R. A., Wagner, J. L., Hannum, C. H., Zlotnick, A.: Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells.J. Interferon Cytokine Res. 16: 611-617, 1996. 3. Kotake, S., Udagawa, N., Takahashi, N., Matsuzaki, K., Itoh, K., Ishiyama, S., Saito, S., Inoue, K., Kamatani, N., Gillespie, M. T., Martin, T. J., Suda, T.IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis.J. Clin. Invest. 103: 1345-1352, 1999.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide. Carrier free (No BSA)

Agent conservateur: Sodium azide, Without preservative

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-Interleukin 17a (ABIN3042799)

Li, Pan, Qiu: "Imbalances of Th17 and Treg cells and their respective cytokines in COPD patients by disease stage." dans: International journal of clinical and experimental medicine, Vol. 7, Issue 12, pp. 5324-9, (2015) (PubMed).

Ma, Wang, Zhao, Pang, Zhang, Jiang, Liu, Mamuti, Wen, Ding: "Th17 cells are associated with the Th1/Th2?cell balance during Echinococcus multilocularis infection." dans: Molecular medicine reports, Vol. 10, Issue 1, pp. 236-40, (2014) (PubMed).

Détails sur Interleukin 17a

Antigène: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Autre désignation: IL17A

Sujet:

Synonyms: Interleukin-17A,IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8,Il17a,Ctla8, Il17,

Tissue Specificity: Restricted to a subset of activated T-cells. .

Background: Interleukin-17A is a protein that in humans is encoded by the IL17A gene. The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Sequence Similarities: Belongs to the immunoglobulin superfamily. CEA family.

Poids moléculaire: 30 kDa

UniProt: Q62386