SDC3 anticorps (N-Term)

N° du produit ABIN3042886

Cet anticorps Lapin Polyclonal détecte spécifiquement SDC3 dans WB et IHC. Il présente une réactivité envers Humain, Souris et Rat et a été mentionné dans 2+ publications.

Aperçu rapide pour SDC3 anticorps (N-Term) (ABIN3042886)

Antigène: SDC3 (Syndecan 3 (SDC3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SDC3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-SDC3 anticorps

Épitope: AA 45-60, N-Term

Fonction: Anti-Syndecan 3/SDC3 Antibody Picoband®

Séquence: AQRWRNENFE RPVDLE

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-Syndecan 3/SDC3 Antibody (ABIN3042886). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of mouse Syndecan 3/SDC3, identical to the related rat sequence, and different from the related human sequence by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat, Mouse
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Berndt, C., Casaroli-Marano, R. P., Vilaro, S., Reina, M. Cloning and characterization of human syndecan-3. J. Cell. Biol. 82: 246-259, 2001. 2. Bobardt, M. D., Saphire, A. C. S., Hung, H.-C., Yu, X., Van der Schueren, B., Zhang, Z., David, G., Gallay, P. A. Syndecan captures, protects, and transmits HIV to T lymphocytes. Immunity 18: 27-39, 2003. 3. de Witte, L., Bobardt, M., Chatterji, U., Degeest, G., David, G., Geijtenbeek, T. B. H., Gallay, P. Syndecan-3 is a dendritic cell-specific attachment receptor for HIV-1.Proc. Nat. Acad. Sci. 104: 19464-19469, 2007. 4. Ha, E., Kim, M.-J., Choi, B.-K., Rho, J.-J., Oh, D.-J., Rho, T.-H., Kim, K.-H., Lee, H. J., Shin, D.-H., Yim, S. V., Baik, H. H., Chung, J.-H., Kim, J. W. Positive association of obesity with single nucleotide polymorphisms of syndecan 3 in the Korean population. J. Clin. Endocr. Metab. 91: 5095-5099, 2006.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-SDC3 (ABIN3042886)

Yao, Zhang, Huang, Li, Gao: "Pleiotrophin and N-syndecan promote perineural invasion and tumor progression in an orthotopic mouse model of pancreatic cancer." dans: World journal of gastroenterology, Vol. 23, Issue 21, pp. 3907-3914, (2017) (PubMed).

Yao, Li, Li, Feng, Gao: "Midkine promotes perineural invasion in human pancreatic cancer." dans: World journal of gastroenterology, Vol. 20, Issue 11, pp. 3018-24, (2014) (PubMed).

Détails sur SDC3

Antigène: SDC3 (Syndecan 3 (SDC3))

Autre désignation: SDC3

Sujet:

Synonyms: Syndecan-3,SYND3,Sdc3,Kiaa0468,

Tissue Specificity: Expressed in most tissues. Most abundant in kidney, bone and liver.

Background: Syndecan-3, also called SYND3 is a protein that in humans is encoded by the SDC3 gene. This gene was assigned to human chromosome 1p35.2. This gene can function as in trans HIV receptors via binding of HIV-1 gp120 to the syndecan heparin sulfate chains. It may play a role in the organization of cell shape by affecting the actin cytoskeleton, and possibly by transferring signals from the cell surface in a sugar-dependent mechanism. In wildtype mice, SDC3 was expressed in hypothalamic regions that control energy balance. It was proposed that oscillation of hypothalamic SDC3 levels physiologically modulates feeding behavior.

Sequence Similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

Poids moléculaire: 60 kDa

UniProt: Q64519

Pathways: Glycosaminoglycan Metabolic Process