HYAL2 anticorps (C-Term)

N° du produit ABIN3043041

Cet anticorps anti-HYAL2 est un anticorps Lapin Polyclonal détectant HYAL2 dans WB. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour HYAL2 anticorps (C-Term) (ABIN3043041)

Antigène: HYAL2 (Hyaluronidase-2 (HYAL2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HYAL2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-HYAL2 anticorps

Épitope: AA 142-157, C-Term

Fonction: Anti-Hyaluronidase-2 HYAL2 Antibody Picoband®

Séquence: VRNWQDKDVY RRLSRQ

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-Hyaluronidase-2 HYAL2 Antibody (ABIN3043041). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human HYAL2, different from the related mouse and rat sequences by three amino acids.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
1. Lepperdinger, G., Strobl, B., Kreil, G. HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity. J. Biol. Chem. 273: 22466-22470, 1998. 2. Rai, S. K., Duh, F.-M., Vigdorovich, V., Danilkovitch-Miagkova, A., Lerman, M. I., Miller, A. D. Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation. Proc. Nat. Acad. Sci. 98: 4443-4448, 2001. 3. Strobl, B., Wechselberger, C., Beier, D. R., Lepperdinger, G. Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase. Genomics 53: 214-219, 1998.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur HYAL2

Antigène: HYAL2 (Hyaluronidase-2 (HYAL2))

Autre désignation: HYAL2

Sujet:

Synonyms: Hyaluronidase-2;Hyal-2;3.2.1.35;Hyaluronoglucosaminidase-2;Lung carcinoma protein 2;LuCa-2;HYAL2;LUCA2;

Tissue Specificity: Widely expressed. No expression detected in adult brain. .

Background: HYAL2 (hyaluronoglucosaminidase 2) also known as hyaluronidase 2, LuCa-2, is an enzyme that in humans is encoded by the HYAL2 gene. HYAL2 cDNAs encode a preprotein with an N-terminal signal peptide. Northern blot analysis indicated that HYAL2 was expressed in all human tissues tested except adult brain, and Western blot analysis detected Hyal2protein in all mouse tissues examined except adult brain. The HYAL2 gene is mapped on 3p21.31. HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored protein on the cell surface and serves as a receptor for entry into the cell of the jaagsiekte sheep retrovirus (JSRV). The findings of Rai et al. (2001) that HYAL2 is a GPI-anchored protein on the cell surface showed that GFP would likely be cleaved from HYAL2 during GPI addition, leaving HYAL2 on the cell surface and resulting in GFP transit to the lysosome for degradation.

Sequence Similarities: Belongs to the glycosyl hydrolase 56 family.

Poids moléculaire: 54 kDa

UniProt: Q12891

Pathways: Transition Metal Ion Homeostasis, Glycosaminoglycan Metabolic Process