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KEAP1 anticorps (AA 25-205)

KEAP1 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3043275
  • Antigène Voir toutes KEAP1 Anticorps
    KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
    Épitope
    • 21
    • 15
    • 15
    • 15
    • 10
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 25-205
    Reactivité
    • 88
    • 57
    • 29
    • 20
    • 18
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    Humain
    Hôte
    • 90
    • 7
    • 1
    Lapin
    Clonalité
    • 89
    • 9
    Polyclonal
    Conjugué
    • 43
    • 10
    • 8
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp KEAP1 est non-conjugé
    Application
    • 85
    • 50
    • 33
    • 26
    • 26
    • 16
    • 10
    • 9
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Fonction
    Rabbit IgG polyclonal antibody for Kelch-like ECH-associated protein 1(KEAP1) detection. Tested with WB in Human.
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for Kelch-like ECH-associated protein 1(KEAP1) detection. Tested with WB in Human.
    Gene Name: kelch-like ECH-associated protein 1
    Protein Name: Kelch-like ECH-associated protein 1
    Purification
    Immunogen affinity purified.
    Immunogène
    E.coli-derived human Keap1 recombinant protein (Position: E25-E205). Human Keap1 shares 96.7% and 97.2% amino acid (aa) sequence identity with mouse and rat Keap1, respectively.
    Isotype
    IgG
    Top Product
    Discover our top product KEAP1 Anticorps primaire
  • Indications d'application
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    Notes: Tested Species: Species with positive results.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Commentaires

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Ni, Wang, Qiu, Pang, Song, Guo: "Bone marrow mesenchymal stem cells protect against bleomycin-induced pulmonary fibrosis in rat by activating Nrf2 signaling." dans: International journal of clinical and experimental pathology, Vol. 8, Issue 7, pp. 7752-61, (2016) (PubMed).

    Deng, Zhu, Mi, Xu, Jiao, Li, Xu, Liu, Xu: "Melatonin antagonizes Mn-induced oxidative injury through the activation of keap1-Nrf2-ARE signaling pathway in the striatum of mice." dans: Neurotoxicity research, Vol. 27, Issue 2, pp. 156-71, (2015) (PubMed).

  • Antigène
    KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
    Autre désignation
    KEAP1 (KEAP1 Produits)
    Synonymes
    anticorps INrf2, anticorps KLHL19, anticorps INRF2, anticorps mKIAA0132, anticorps Inrf2, anticorps fb36f11, anticorps keap1, anticorps wu:fb36f11, anticorps KEAP1, anticorps klhl19, anticorps zgc:171654, anticorps kelch like ECH associated protein 1, anticorps kelch-like ECH-associated protein 1, anticorps Kelch-like ECH-associated protein 1, anticorps kelch-like ECH-associated protein 1a, anticorps kelch like ECH associated protein 1 L homeolog, anticorps kelch-like ECH-associated protein 1b, anticorps KEAP1, anticorps Keap1, anticorps keap1a, anticorps keap1, anticorps keap1.L, anticorps keap1b
    Sujet
    KEAP1 (KELCH-LIKE ECH-ASSOCIATED PROTEIN 1), is a protein that in humans is encoded by the Keap1 gene. The KIAA0132 gene is mapped on 19p13.2. Keap1 contains a central BTB/POZ domain and a C-terminal double glycine repeat (DGR), or Kelch, module. Keap1 has been shown to interact with Nrf2, a master regulator of the antioxidant response, which is important for the amelioration of oxidative stress. In the presence of the electrophilic agent diethylmalate, Nrf2 activity is released from Keap1 and Nrf2 translocate to the nucleus. Under quiescent conditions, Nrf2 is anchored in the cytoplasm through binding to Keap1, which, in turn, facilitates the ubiquitination and subsequent proteolysis of Nrf2. Because Nrf2 activation leads to a coordinated antioxidant and anti-inflammatory response, and Keap1 represses Nrf2 activation, Keap1 has become a very attractive drug target.

    Synonyms: Cytosolic inhibitor of Nrf2 antibody|INrf 2 antibody|INrf2 antibody|Keap 1 antibody|KEAP1 antibody|KEAP1_HUMAN antibody|Kelch like ECH associated protein 1 antibody|Kelch like family member 19 antibody|Kelch like protein 19 antibody|Kelch-like ECH-associated protein 1 antibody|Kelch-like protein 19 antibody|KIAA0132 antibody|KLHL 19 antibody|KLHL19 antibody|MGC10630 antibody|MGC1114 antibody|MGC20887 antibody|MGC4407 antibody|MGC9454 antibody
    ID gène
    9817
    UniProt
    Q14145
    Pathways
    Maintenance of Protein Location
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