TJP1 anticorps (AA 1178-1527)

N° du produit ABIN3043312

Cet anticorps Lapin Polyclonal détecte spécifiquement TJP1 dans WB, IHC, FACS, IF et ICC. Il présente une réactivité avec des échantillons de Humain, Souris et Rat. Il a été cité dans 4+ publications.

Aperçu rapide pour TJP1 anticorps (AA 1178-1527) (ABIN3043312)

Antigène: TJP1 (Tight Junction Protein 1 (TJP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TJP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-TJP1 anticorps

Épitope: AA 1178-1527

Fonction: Anti-ZO1 tight junction protein/TJP1 Antibody

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human TJP1 shares 82% amino acid (aa) sequence identity with mouse TJP1.

Attributs du produit: Anti-ZO1 tight junction protein/TJP1 Antibody. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human TJP1 recombinant protein (Position: H1178-F1527). Human TJP1 shares 82% amino acid (aa) sequence identity with mouse TJP1.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-TJP1 (ABIN3043312)

Liu, Mei, Xu, Yu, Shi, Zhang, Wang, Zhang, Gao, Zhang, He: "Dual Receptor Recognizing Cell Penetrating Peptide for Selective Targeting, Efficient Intratumoral Diffusion and Synthesized Anti-Glioma Therapy." dans: Theranostics, Vol. 6, Issue 2, pp. 177-91, (2017) (PubMed).

Subramani, Ponnalagu, Krishna, Jeyabalan, Chevour, Sharma, Jayadev, Shetty, Begum, Archunan, Das: "Resveratrol reverses the adverse effects of bevacizumab on cultured ARPE-19 cells." dans: Scientific reports, Vol. 7, Issue 1, pp. 12242, (2017) (PubMed).

Lv, Phuong, Jin, Li, Xu: "Protection by simvastatin on hyperglycemia-induced endothelial dysfunction through inhibiting NLRP3 inflammasomes." dans: Oncotarget, Vol. 8, Issue 53, pp. 91291-91305, (2017) (PubMed).

Wen, Huang, Zhang, Zhang, Chen, Gu, Hao: "Resveratrol attenuates diabetic nephropathy via modulating angiogenesis." dans: PLoS ONE, Vol. 8, Issue 12, pp. e82336, (2013) (PubMed).

Détails sur TJP1

Antigène: TJP1 (Tight Junction Protein 1 (TJP1))

Autre désignation: TJP1

Sujet:

Background: Tight junction protein ZO-1 is a protein that in humans is encoded by the TJP1 gene. It is mapped to 15q13.1. This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. It has been found that injected CagA associates with the epithelial tight-junction scaffolding protein TJP1 and the transmembrane protein junctional adhesion molecule, causing an ectopic assembly of tight junction components at sites of bacterial attachment, and altering the composition and function of the apical-junctional complex.

Gene Full Name: tight junction protein 1

Sequence Similarities: Belongs to the MAGUK family.

Poids moléculaire: 220 kDa

ID gène: 7082

UniProt: Q07157

Pathways: Carbohydrate Homeostasis, Cell-Cell Junction Organization