SERPINB2 anticorps (AA 1-180)

N° du produit ABIN3043329

Cet anticorps anti-SERPINB2 est un anticorps Lapin Polyclonal détectant SERPINB2 dans WB et IHC. Adapté pour Humain.

Aperçu rapide pour SERPINB2 anticorps (AA 1-180) (ABIN3043329)

Antigène: SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SERPINB2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-SERPINB2 anticorps

Épitope: AA 1-180

Fonction: Anti-SerpinB2 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-SerpinB2 Antibody Picoband® (ABIN3043329). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human SerpinB2 recombinant protein (Position: M1-K180). Human SerpinB2 shares 70% and 66% amino acid (aa) sequence identity with mouse and rat SerpinB2, respectively.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human
1. Corsetti JP, et al. Plasminogen activator inhibitor-2 polymorphism associates with recurrent coronary event risk in patients with high HDL and C-reactive protein levels. PLoS One, 2013. 2. Huang Z, et al. SERPINB2 down-regulation contributes to chemoresistance in head and neck cancer. Mol Carcinog, 2014 Oct. 3. Jin Y, et al. Expression of plasminogen activator inhibitor-2 is negatively associated with invasive potential in hepatocellular carcinoma cells. Chin Med Sci J, 2013 Mar. 4. Zhou L, et al. Low expression of PAI-2 as a novel marker of portal vein tumor thrombosis and poor prognosis in hepatocellular carcinoma. World J Surg, 2013 Mar.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur SERPINB2

Antigène: SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Autre désignation: SERPINB2

Classe de substances: Amino Acid

Sujet:

Synonyms: Plasminogen activator inhibitor 2,PAI-2,Monocyte Arg-serpin,Placental plasminogen activator inhibitor,Serpin B2,Urokinase inhibitor,SERPINB2,PAI2, PLANH2,

Tissue Specificity: Plasma. .

Background: SERPINB2 is also known as PAI or PAI2. Plasminogen activator inhibitor-2 (placental PAI) is acoagulation factor that inactivates tPA and urokinase. It is present in most cells, especially monocytes/macrophages. PAI-2 exists in two forms, a 60- kDa extracellular glycosylated form and a 43- kDa intracellular form. It is present only at detectable quantities in blood during pregnancy, as it is produced by the placenta, and may explain partially the increased rate of thrombosisduring pregnancy. The majority of expressed PAI-2 remains unsecreted due to the presence of an inefficient internal signal peptide.

Sequence Similarities: Belongs to the semaphorin family.

Poids moléculaire: 47 kDa

ID gène: 5055

UniProt: P05120

Pathways: Autophagy