NUMB anticorps (N-Term)

N° du produit ABIN3043374

Détail du produit anti-NUMB anticorps

Antigène: NUMB (Numb Homolog (NUMB))

Épitope: AA 194-220, N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NUMB est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for Protein numb homolog(NUMB) detection. Tested with WB in Human,Mouse.

Séquence: SFRVTTATEQ AEREEIMKQM QDAKKAE

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Protein numb homolog(NUMB) detection. Tested with WB in Human,Mouse.
Gene Name: numb homolog (Drosophila)
Protein Name: Protein numb homolog

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human NUMB(194-220aa SFRVTTATEQAEREEIMKQMQDAKKAE), different from the related mouse and rat sequences by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, The detection limit for NUMB is approximately 0.25 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Détails sur NUMB

Antigène: NUMB (Numb Homolog (NUMB))

Autre désignation: NUMB (NUMB Produits)

Synonymes: anticorps C14orf41, anticorps S171, anticorps c14_5527, anticorps Nb, anticorps NUMB, endocytic adaptor protein, anticorps numb homolog (Drosophila), anticorps NUMB, anticorps Numb, anticorps numb

Sujet: Protein numb homolog is a protein that in humans is encoded by the NUMB gene. It is mapped to 14q24.2 to q24.3. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. The primary function of Numb in cell differentiation is as an inhibitor of Notch signaling which is essential for maintaining self-renewal potential in stem and progenitor cells. Numb also plays a crucial role in asymmetrical cell division during development, allowing for differential cell fate specification in the central and peripheral nervous systems. What's more, the numb gene protein product controls binary cell fate decisions in the peripheral and central nervous systems of both invertebrates and mammals during neurogenesis.

Synonyms: c14_5527 antibody|C14orf41 antibody|FLJ31314 antibody|h Numb antibody|h-Numb antibody|Numb antibody|Numb homolog (Drosophila) antibody|Numb homolog antibody|Numb protein homolog antibody|NUMB_HUMAN antibody|Protein numb homolog antibody|Protein S171 antibody|S171 antibody

ID gène: 8650

UniProt: P49757

Pathways: Cell-Cell Junction Organization