PAX6 anticorps (Middle Region)

N° du produit ABIN3043379

Détail du produit anti-PAX6 anticorps

Antigène: PAX6 (Paired Box 6 (PAX6))

Épitope: AA 195-233, Middle Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAX6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Paired box protein Pax-6(PAX6) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Séquence: EDSDEAQMRL QLKRKLQRNR TSFTQEQIEA LEKEFERTH

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Paired box protein Pax-6(PAX6) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: paired box 6
Protein Name: Paired box protein Pax-6

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human PAX6 (195-233aa EDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTH), identical to the related mouse and rat sequences.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-PAX6 (ABIN3043379)

Liu, Novak, Pepin, Maschhoff, Worner, Chen, Zhang, Hu: "A congenital hydrocephalus-causing mutation in Trim71 induces stem cell defects via inhibiting Lsd1 mRNA translation." dans: EMBO reports, Vol. 24, Issue 2, pp. e55843, (2023) (PubMed).

Détails sur PAX6

Antigène: PAX6 (Paired Box 6 (PAX6))

Autre désignation: PAX6 (PAX6 Produits)

Synonymes: anticorps pax6, anticorps an2, anticorps mgda, anticorps wagr, anticorps pax-6, anticorps pax6a, anticorps xpax6, anticorps XLPAX6, anticorps MGC52531, anticorps PAX-6, anticorps AN, anticorps AN2, anticorps D11S812E, anticorps MGDA, anticorps WAGR, anticorps Pax-6, anticorps pax6b, anticorps 1500038E17Rik, anticorps AEY11, anticorps Dey, anticorps Gsfaey11, anticorps Sey, anticorps PAXZF-A, anticorps Pax6.1, anticorps cb280, anticorps fc20e07, anticorps pax-a, anticorps pax[zf-a], anticorps paxzfa, anticorps wu:fc20e07, anticorps zfpax-6a, anticorps zfpax-6b, anticorps paired box 6, anticorps paired box 6 L homeolog, anticorps paired box 6 S homeolog, anticorps paired box 6a, anticorps PAX6, anticorps pax6, anticorps Pax6, anticorps pax6.L, anticorps pax6.S, anticorps pax6a

Sujet: Paired box protein Pax-6, also known as aniridia type II protein (AN2) or oculorhombin, is a protein that in humans is encoded by the PAX6 gene. This gene encodes a homeobox and paired domain-containing protein that binds DNA and functions as a regulator of transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. In addition, this gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms.

Synonyms: AN 2 antibody|AN antibody|AN2 antibody|Aniridia type II protein antibody|D11S812E antibody|FVH1 antibody|MGC17209 antibody|MGDA antibody|Oculorhombin antibody|Paired box 6 antibody|Paired box gene 6 (aniridia keratitis) antibody|Paired Box Gene 6 antibody|Paired box homeotic gene 6 antibody|Paired box protein Pax-6 antibody|Paired box protein Pax6 antibody|PAX 6 antibody|PAX6 antibody| PAX6_HUMAN antibody|Sey antibody|WAGR antibody

ID gène: 5080

UniProt: P26367

Pathways: Peptide Hormone Metabolism, Carbohydrate Homeostasis