OPA1 anticorps (C-Term)

N° du produit ABIN3043457

Détail du produit anti-OPA1 anticorps

Antigène: OPA1 (Optic Atrophy 1 (Autosomal Dominant) (OPA1))

Épitope: AA 919-955, C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OPA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Dynamin-like 120 kDa protein, mitochondrial(OPA1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Séquence: EDGEKKIKLL TGKRVQLAED LKKVREIQEK LDAFIEA

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Dynamin-like 120 kDa protein, mitochondrial(OPA1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: optic atrophy 1 (autosomal dominant)
Protein Name: Dynamin-like 120 kDa protein, mitochondrial

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human OPA1 (919-955aa EDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEA), different from the related mouse and rat sequences by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Détails sur OPA1

Antigène: OPA1 (Optic Atrophy 1 (Autosomal Dominant) (OPA1))

Autre désignation: OPA1 (OPA1 Produits)

Synonymes: anticorps 1200011N24Rik, anticorps AI225888, anticorps AI847218, anticorps lilr3, anticorps mKIAA0567, anticorps MGM1, anticorps NPG, anticorps NTG, anticorps largeG, anticorps fk62d06, anticorps wu:fb77a10, anticorps wu:fk62d06, anticorps zgc:92092, anticorps OPA1, mitochondrial dynamin like GTPase, anticorps optic atrophy 1 (autosomal dominant), anticorps Opa1, anticorps OPA1, anticorps opa1

Sujet: Dynamin-like 120 kDa protein, mitochondrial is a protein that in humans is encoded by the OPA1 gene. It is mapped to 3q29. This protein regulates mitochondrial fusion and cristae structure in the inner mitochondrial membrane (IMM) and contributes to ATP synthesis and apoptosis. This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms: Dynamin like 120 kDa protein antibody|Dynamin like 120 kDa protein, mitochondrial antibody|Dynamin-like 120 kDa protein, form S1 antibody|FLJ12460 antibody|Juvenile kjer type optic atrophy antibody|KIAA0567 antibody|KJER type antibody|Large GTP binding protein antibody|largeG antibody|MGM1 antibody|Mitochondrial dynamin like 120 kDa protein antibody|Mitochondrial dynamin like GTPase antibody| NPG antibody|NTG antibody|OAK antibody|OPA 1 antibody|opa1 antibody|OPA1 gene antibody|OPA1_HUMAN antibody|Optic atrophy 1 (autosomal dominant) antibody|OPTIC ATROPHY 1 antibody|Optic atrophy 1 gene protein antibody|Optic atrophy 1 homolog (human) antibody| Optic atrophy protein 1 antibody|Optic atrophy protein 1 homolog antibody|

ID gène: 4976

UniProt: O60313

Pathways: Tube Formation