Decorin anticorps (AA 31-359)

N° du produit ABIN3043487

L’anticorps Lapin Polyclonal anti-Decorin a été validé pour WB et IHC. Il convient pour détecter Decorin dans des échantillons de Humain, Souris et Rat. Il y a 3+ publications disponibles.

Aperçu rapide pour Decorin anticorps (AA 31-359) (ABIN3043487)

Antigène: Decorin (DCN)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Decorin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Decorin anticorps

Épitope: AA 31-359

Fonction: Anti-Decorin/DCN Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-Decorin/DCN Antibody Picoband® (ABIN3043487). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Decorin recombinant protein (Position: D31-K359). Human Decorin shares 80% and 77% amino acid (aa) sequences identity with mouse and rat Decorin, respectively.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Danielson, K. G., Fazzio, A., Cohen, I., Cannizzaro, L. A., Eichstetter, I., Iozzo, R. V. : The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5-prime untranslated region, and mapping of the gene to chromosome 12q23. Genomics 15: 146-160, 1993. 2. Vetter, U., Vogel, W., Just, W., Young, M. F., Fisher, L. W. : Human decorin gene: intron-exon junctions and chromosomal localization. Genomics 15: 161-168, 1993. 3. Scholzen, T., Solursh, M., Suzuki, S., Reiter, R., Morgan, J. L., Buchberg, A. M., Siracusa, L. D., Iozzo, R. V. : The murine decorin: complete cDNA cloning, genomic organization, chromosomal assignment, and expression during organogenesis and tissue differentiation. J. Biol. Chem. 269: 28270-28281, 1994.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Références pour anticorps anti-Decorin (ABIN3043487)

Lai, Chen, Chen, Ruan, He, Chen, Tang, Wang: "Overexpression of decorin promoted angiogenesis in diabetic cardiomyopathy via IGF1R-AKT-VEGF signaling." dans: Scientific reports, Vol. 7, pp. 44473, (2018) (PubMed).

Han, Wang, Jiang, Ma, Tian, Zang, Ma: "An Animal Model of Modic Changes by Embedding Autogenous Nucleus Pulposus inside Subchondral Bone of Lumbar Vertebrae." dans: Scientific reports, Vol. 6, pp. 35102, (2016) (PubMed).

Huang, Zou, Shi, Zhang, Pen, Zhang, Gao, Wang: "The effect of electroacupuncture on the extracellular matrix synthesis and degradation in a rabbit model of disc degeneration." dans: Evidence-based complementary and alternative medicine : eCAM, Vol. 2014, pp. 731395, (2014) (PubMed).

Détails sur Decorin

Antigène: Decorin (DCN)

Autre désignation: DCN

Sujet:

Synonyms: Decorin,Bone proteoglycan II,PG-S2,PG40,DCN,SLRR1B,

Tissue Specificity: Expressed at low levels in the lung, kidney and spleen.

Background: Decorin is a protein that in humans is encoded by the DCN gene. This gene is mapped to 12q21.3. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a protein core containing leucine repeats with a glycosaminoglycan (GAG) chain consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS). Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. And it also may play a role in epithelial/mesenchymal interactions during organ development and shaping. Decorin has been shown to have anti-tumorigenic properties in an experimental murine tumor model and is capable of suppressing the growth of various tumor cell lines.

Sequence Similarities: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.

Poids moléculaire: 40-50 kDa, 80-140 kDa.

ID gène: 1634

UniProt: P07585

Pathways: Glycosaminoglycan Metabolic Process