Decorin anticorps (AA 31-359)

N° du produit ABIN3043487

Détail du produit anti-Decorin anticorps

Antigène: Decorin (DCN)

Épitope: AA 31-359

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Decorin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Decorin(DCN) detection. Tested with WB, IHC-P in Human,Rat.

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Decorin(DCN) detection. Tested with WB, IHC-P in Human,Rat.
Gene Name: decorin
Protein Name: Decorin

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Decorin recombinant protein (Position: D31-K359). Human Decorin shares 80% and 77% amino acid (aa) sequences identity with mouse and rat Decorin, respectively.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, The detection limit for Decorin is approximately 0.5 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-Decorin (ABIN3043487)

Lai, Chen, Chen, Ruan, He, Chen, Tang, Wang: "Overexpression of decorin promoted angiogenesis in diabetic cardiomyopathy via IGF1R-AKT-VEGF signaling." dans: Scientific reports, Vol. 7, pp. 44473, (2018) (PubMed).

Han, Wang, Jiang, Ma, Tian, Zang, Ma: "An Animal Model of Modic Changes by Embedding Autogenous Nucleus Pulposus inside Subchondral Bone of Lumbar Vertebrae." dans: Scientific reports, Vol. 6, pp. 35102, (2016) (PubMed).

Huang, Zou, Shi, Zhang, Pen, Zhang, Gao, Wang: "The effect of electroacupuncture on the extracellular matrix synthesis and degradation in a rabbit model of disc degeneration." dans: Evidence-based complementary and alternative medicine : eCAM, Vol. 2014, pp. 731395, (2014) (PubMed).

Détails sur Decorin

Antigène: Decorin (DCN)

Autre désignation: DCN (DCN Produits)

Synonymes: anticorps CSCD, anticorps DSPG2, anticorps PG40, anticorps PGII, anticorps PGS2, anticorps SLRR1B, anticorps DC, anticorps mDcn, anticorps cscd, anticorps dspg2, anticorps pg40, anticorps pgii, anticorps pgs2, anticorps slrr1b, anticorps decorin, anticorps decorin L homeolog, anticorps DCN, anticorps Dcn, anticorps dcn.L, anticorps dcn

Sujet: Decorin is a protein that in humans is encoded by the DCN gene. This gene is mapped to 12q21.3. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a protein core containing leucine repeats with a glycosaminoglycan (GAG) chain consisting of either chondroitin sulfate(CS) or dermatan sulfate(DS). Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. And it also may play a role in epithelial/mesenchymal interactions during organ development and shaping. Decorin has been shown to have anti-tumorigenic properties in an experimental murine tumor model and is capable of suppressing the growth of various tumor cell lines.

Synonyms: Bone proteoglycan II antibody|CSCD antibody|DCN antibody|DCN protein antibody|Decorin antibody|Decorin proteoglycan antibody|Dermatan sulphate proteoglycans II antibody|DKFZp686J19238 antibody|DSPG 2 antibody|DSPG2 antibody|PG 40 antibody|PG II antibody|PG S2 antibody|PG-S2 antibody|PG40 antibody|PGII antibody|PGS 2 antibody|PGS2 antibody|PGS2_HUMAN antibody|Proteoglycan core protein antibody|SLRR1B antibody|Small leucine rich protein 1B antibody

ID gène: 1634

UniProt: P07585

Pathways: Glycosaminoglycan Metabolic Process