GSTA1 anticorps (N-Term)

N° du produit ABIN3043839

Cet anticorps anti-GSTA1 est un anticorps Lapin Polyclonal détectant GSTA1 dans WB, IHC et IF. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour GSTA1 anticorps (N-Term) (ABIN3043839)

Antigène: GSTA1 (Glutathione S-Transferase alpha 1 (GSTA1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GSTA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-GSTA1 anticorps

Épitope: AA 63-97, N-Term

Fonction: Anti-GSTA1/GSTA2/GSTA3/GSTA4/GSTA5 Antibody Picoband®

Séquence: MKLVQTRAIL NYIASKYNLY GKDIKERALI DM

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-GSTA1/GSTA2/GSTA3/GSTA4/GSTA5 Antibody Picoband® (ABIN3043839). Tested in IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human GSTA1/A2/A3/A4/A5, different from the related mouse and rat sequences by five amino acids.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat
Immunofluorescence, 2 μg/mL, Mouse, Rat
1. Atkinson, HJ, Babbitt, PC (Nov 24, 2009). "Glutathione transferases are structural and functional outliers in the thioredoxin fold.". Biochemistry 48 (46): 11108-16. 2. Boyer TD (March 1989). "The glutathione S-transferases: an update". Hepatology 9(3): 486-96.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur GSTA1

Antigène: GSTA1 (Glutathione S-Transferase alpha 1 (GSTA1))

Autre désignation: GSTA1

Sujet:

Synonyms: Glutathione S-transferase A1, 2.5.1.18, GST HA subunit 1, GST class-alpha member 1, GST-epsilon, GSTA1-1, GTH1, Glutathione S-transferase A1, N-terminally processed, GSTA1,

Tissue Specificity: Liver.

Background: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver (hepatocytes) and kidney (proximal tubules). In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity, thereby protecting the cells from reactive oxygen species and the products of peroxidation.

Sequence Similarities: Contains 1 HMG box DNA-binding domain.

Poids moléculaire: 26 kDa

ID gène: 2938, 2939, 2940

UniProt: P08263