DPYD anticorps (N-Term)

N° du produit ABIN3044151

Détail du produit anti-DPYD anticorps

Antigène: DPYD (Dihydropyrimidine Dehydrogenase (DPYD))

Épitope: AA 33-52, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DPYD est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for Dihydropyrimidine dehydrogenase[NADP(+)](DPYD) detection. Tested with WB in Human,Mouse,Rat.

Séquence: AKKLDKKHWK RNPDKNCFNC

Réactivité croisée (Details): Predicted Cross Reactivity: mouse, rat
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Attributs du produit: Rabbit IgG polyclonal antibody for Dihydropyrimidine dehydrogenase[NADP(+)](DPYD) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: dihydropyrimidine dehydrogenase
Protein Name: Dihydropyrimidine dehydrogenase [NADP(+)](DHPDHase/DPD)

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human DPYD(33-52aa AKKLDKKHWKRNPDKNCFNC), different from the related rat and mouse sequences by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur DPYD

Antigène: DPYD (Dihydropyrimidine Dehydrogenase (DPYD))

Autre désignation: DPYD (DPYD Produits)

Synonymes: anticorps DPYD, anticorps dpyd, anticorps zgc:77205, anticorps AI315208, anticorps DPD, anticorps E330028L06Rik, anticorps DHP, anticorps DHPDHASE, anticorps dhp, anticorps dhpdhase, anticorps dpd, anticorps 14.t00017, anticorps DDBDRAFT_0189681, anticorps DDBDRAFT_0231100, anticorps DDB_0189681, anticorps DDB_0231100, anticorps dpyda, anticorps zgc:153505, anticorps dihydropyrimidine dehydrogenase, anticorps dihydropyrimidine dehydrogenase b, anticorps dihydropyrimidine dehydrogenase L homeolog, anticorps dihydropyrimidine dehydrogenase [NADP(+)], anticorps dihydropyrimidine dehydrogenase a, tandem duplicate 1, anticorps DPYD, anticorps Dpyd, anticorps dpydb, anticorps dpyd.L, anticorps EHI_012980, anticorps LOC5573038, anticorps EDI_044620, anticorps pyd1, anticorps dpyda.1

Sujet: DPYD(Dihydropyrimidine Dehydrogenase), also called DPD, is an enzyme that in humans is encoded by the DPYD gene. The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. The structure of the DPYD gene contains 23 exons spanning about 950 kb. Using somatic cell hybrid strategies, the DPYD gene is mapped to the centromeric region of chromosome 1 between 1p22 and 1q21. By fluorescence in situ hybridization, the DPYD gene is mapped to 1p22. The highest level of DPD was found in monocytes followed by that in lymphocytes, granulocytes, and platelets, whereas no significant activity of DPD could be detected in erythrocytes. The activity of DPD in peripheral blood mononuclear cells was intermediate between that observed in monocytes and lymphocytes. By cDNA microarray, Western blot analysis, and luciferase reporter assay, the transcription factor LSF was identified as a positive regulator of DPYD.

Synonyms: DHP antibody|DHPDHase antibody|Dihydropyrimidine dehydrogenase[NADP(+)] antibody|Dihydropyrimidine dehydrogenase[NADP+] antibody|Dihydropyrimidine dehydrogenase antibody|Dihydrothymine dehydrogenase antibody|Dihydrouracil dehydrogenase antibody|DPD antibody|DPYD antibody|DPYD_HUMAN antibody|MGC132008 antibody|MGC70799 antibody|OTTHUMP00000058954 antibody

UniProt: Q12882

Pathways: Ribonucleoside Biosynthetic Process