Haptoglobin anticorps (Middle Region)

N° du produit ABIN3044209

Cet anticorps Lapin Polyclonal détecte spécifiquement Haptoglobin dans WB et IHC. Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour Haptoglobin anticorps (Middle Region) (ABIN3044209)

Antigène: Haptoglobin (HP)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Haptoglobin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Haptoglobin anticorps

Épitope: AA 294-309, Middle Region

Fonction: Anti-Haptoglobin/HP Antibody Picoband®

Séquence: DHLKYVMLPV ADQDQC

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Rabbit IgG polyclonal antibody for Haptoglobin(HP) detection. Tested with WB, IHC-P in Human.
Gene Name: haptoglobin
Protein Name: Haptoglobin

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human Haptoglobin.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human
1. Asakawa, J., Kodaira, M., Nakamura, N., Satoh, C., Fujita, M. Chimerism in humans after intragenic recombination at the haptoglobin locus during early embryogenesis. Proc. Nat. Acad. Sci. 96: 10314-10319, 1999. 2. Bensi, G., Raugei, G., Klefenz, H., Cortese, R. Structure and expression of the human haptoglobin locus. EMBO J. 4: 119-126, 1985. 3. Bloom, G. E., Gerald, P. S., Reisman, L. E. Ring D chromosome: a second case associated with anomalous haptoglobin inheritance. Science 156: 1746-1748, 1967.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-Haptoglobin (ABIN3044209)

Cao, Chen, Gao, Hu, Liang, Xiao: "Identification of a protein associated with the activity of cytokine-induced killer cells." dans: Oncology letters, Vol. 14, Issue 6, pp. 6937-6942, (2017) (PubMed).

Détails sur Haptoglobin

Antigène: Haptoglobin (HP)

Autre désignation: HP

Sujet:

Synonyms: Haptoglobin,Zonulin,Haptoglobin alpha chain,Haptoglobin beta chain,HP,

Tissue Specificity: Expressed by the liver and secreted in plasma.

Background: Haptoglobin (HP), is a protein that in humans is encoded by the HP gene. Haptoglobin, a plasma glycoprotein that binds free hemoglobin, has a tetrameric structure of 2 alpha and 2 beta polypeptides that are covalently associated by disulfide bonds. Haptoglobin is homologous to serine proteases of the chymotrypsinogen family. In the chimpanzee, there are 3 genes in the haptoglobin family (haptoglobin, HP, haptoglobin-related, HPR, and haptoglobin-primate, HPP), whereas only 2 genes exist in humans (HP and HPR). There are similarities between the primary structures of the alpha chain and of light chains of gamma globulins. The alpha haptoglobin locus is on the long arm of chromosome 16, where its exact cytogenetic location is 16q22.2. A major function of haptoglobin is to bind hemoglobin (Hb) to form a stable Hp-Hb complex and thereby prevent Hb-induced oxidative tissue damage. Haptoglobin is an unusual secretory protein in that it is proteolytically processed in the endoplasmic reticulum and not in the Golgi. The human haptoglobin HP*2 allele contains a 1.7-kb intragenic duplication that arose after a unique nonhomologous recombination between the prototype HP*1 alleles.

Sequence Similarities: Belongs to the peptidase S1 family.

Poids moléculaire: 45 kDa

UniProt: P00738

Pathways: Transition Metal Ion Homeostasis