HAVCR1 anticorps (C-Term)

N° du produit ABIN3044229

Cet anticorps anti-HAVCR1 Polyclonal Lapin (ABIN3044229) détecte spécifiquement HAVCR1 dans WB et IHC. L’anticorps est réactif avec des échantillons de Rat.

Aperçu rapide pour HAVCR1 anticorps (C-Term) (ABIN3044229)

Antigène: HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HAVCR1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-HAVCR1 anticorps

Épitope: AA 289-307, C-Term

Fonction: Anti-TIM 1/HAVCR1 Antibody

Séquence: HPRAEDNIYI IEDRSRGAE

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-TIM 1/HAVCR1 Antibody (ABIN3044229). Tested in IHC, WB applications. This antibody reacts with Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of rat TIM 1.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Rat, -
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Rat
Western blot, 0.1-0.5 μg/mL, Rat

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur HAVCR1

Antigène: HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))

Autre désignation: HAVCR1

Sujet:

Synonyms: Hepatitis A virus cellular receptor 1 homolog,HAVcr-1,Kidney injury molecule 1,KIM-1,T cell immunoglobulin and mucin domain-containing protein 1,TIMD-1,Havcr1,Kim1,

Tissue Specificity: Expressed at a low level in normal kidney but are increased dramatically in postischemic kidney. Expressed in proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-positive epithelial cells in regenerating proximal tubules. .

Background: KIM1 (KIDNEY INJURY MOLECULE 1), also known as HAVCR1, HAVCR or TIM1, is a protein that in humans is encoded by the KIM1 gene. The KIM1 gene is mapped to 5q33.3. Biochemical, mutational, and cell adhesion analyses confirm that Tim1 is capable of homophilic Tim-Tim interactions. The features identified in murine KIM1 is conserved in human KIM1. The KIM1 protein is indeed a receptor for the virus through the infection of canine osteogenic sarcoma cells expressing HAVCR1 with HAV. Using a monoclonal antibody to mouse Tim1, Tim1 is expressed after activation of naive T cells and on T cells differentiated in Th2-polarizing conditions. Ectopic expression of KIM1 during mouse T-cell differentiation leads to production of the Th2-type cytokine Il4, but not the Th1-type cytokine Ifng. KIM1-expressing epithelial cells internalized apoptotic bodies, and Kim1 is ly responsible for phagocytosis in cultured primary rat tubule epithelial cells and in porcine and canine epithelial cell lines.

Sequence Similarities: Belongs to the immunoglobulin superfamily. TIM family.

Poids moléculaire: 50 kDa

UniProt: O54947