Netrin 1 anticorps (N-Term)

N° du produit ABIN3044248

Détail du produit anti-Netrin 1 anticorps

Antigène: Netrin 1 (NTN1)

Épitope: AA 32-51, N-Term

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Netrin 1 est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for Netrin-1(NTN1) detection. Tested with WB in Human,Mouse,Rat.

Séquence: AGQAAQPDPC SDENGHPRRC

Réactivité croisée (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Attributs du produit: Rabbit IgG polyclonal antibody for Netrin-1(NTN1) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: netrin 1
Protein Name: Netrin-1

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human Netrin 1(32-51aa AGQAAQPDPCSDENGHPRRC), identical to the related rat and mouse sequences.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Références pour anticorps anti-Netrin 1 (ABIN3044248)

Qian-hua, Shao-ping, Jian-wen, Yun, Li: "Reduced expression of netrin-1 is associated with fetal growth restriction." dans: Molecular and cellular biochemistry, Vol. 350, Issue 1-2, pp. 81-7, (2011) (PubMed).

Zhong, Zou, Zhao, Hu, Xie: "Effect of different concentrations of neogenin on proliferation, apoptosis and related proliferative factors in human trophoblasts." dans: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 30, Issue 4, pp. 500-4, (2010) (PubMed).

Détails sur Netrin 1

Antigène: Netrin 1 (NTN1)

Autre désignation: NTN1 (NTN1 Produits)

Synonymes: anticorps ntn1-A, anticorps Netrin-1, anticorps NTN1, anticorps unc-6, anticorps MGC147073, anticorps NTN1L, anticorps AI561871, anticorps BC019633, anticorps netrin-1, anticorps netrin 1 L homeolog, anticorps netrin 1, anticorps ntn1.L, anticorps NTN1, anticorps ntn1, anticorps Ntn1

Sujet: Netrin-1(NTN1), also known as NTN1L, is a diffusible protein made by floor plate cells. Netrin-1 is found in the floor plate and neuroepithelial cells of the ventral region of the spinal cord, as well as other locations in the nervous system including the somatic mesoderm, pancreas and cardiac muscle. The human NTN1 gene is mapped to chromosome 17p13-p12 by FISH. Netrin-1 can attract spinal commissural axons and repel trochlear axons in vitro. And netrin-1 expression confers a selective advantage for tumor cell survival. The binding of netrin-1 to DCC appears to depend on the presence of a coreceptor or accessory proteins. Adenosine A2b receptor is actually a netrin-1 receptor and induces cAMP accumulation on binding netrin-1, and that netrin-1-dependent outgrowth of dorsal spinal cord axons directly involves A2b. Netrin-1 can promote intestinal tumor development, probably by regulating cell survival. Thus, a netrin-1 receptor or receptors function as conditional tumor suppressors. Expression of Unc5b triggered endothelial cell repulsion in response to netrin-1 in vitro, whereas a truncated Unc5b lacking the intracellular signaling domain failed to induce repulsion.

Synonyms: NET1_HUMAN antibody|Netrin 1, mouse, homolog of antibody|Netrin 1-like antibody|Netrin-1 antibody|Netrin1 antibody|Ntn 1 antibody|NTN 1L antibody|Ntn1 antibody|NTN1L antibody|Unc6 antibody

UniProt: O95631

Pathways: Regulation of Cell Size