TACR1 anticorps (Middle Region)

N° du produit ABIN3044262

Détail du produit anti-TACR1 anticorps

Antigène: TACR1 (Tachykinin Receptor 1 (TACR1))

Épitope: AA 231-245, Middle Region

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TACR1 est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for Substance-P receptor(TACR1) detection. Tested with WB in Human,Mouse,Rat.

Séquence: DSSDRYHEQV SAKRK

Réactivité croisée (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Attributs du produit: Rabbit IgG polyclonal antibody for Substance-P receptor(TACR1) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: tachykinin receptor 1
Protein Name: Substance-P receptor(SPR)

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human TACR1(231-245aa DSSDRYHEQVSAKRK), identical to the related rat and mouse sequences.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur TACR1

Antigène: TACR1 (Tachykinin Receptor 1 (TACR1))

Autre désignation: TACR1 (TACR1 Produits)

Synonymes: anticorps NK1R, anticorps NKIR, anticorps SPR, anticorps TAC1R, anticorps Nk1r, anticorps Spr, anticorps Tac1r, anticorps nk1R, anticorps Tacr1, anticorps ASPR, anticorps tachykinin receptor 1, anticorps TACR1, anticorps Tacr1

Sujet: The tachykinin receptor 1(TACR1) also known as neurokinin 1 receptor(NK1R) or substance P receptor(SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene. Tachykinin receptor 1 consists of 407 amino acid residues, and it has a molecular weight of 58.000. Tachykinin receptor 1, as well as the other tachykinin receptors, is made of seven hydrophobic transmembrane(TM) domains with three extracellular and three intracellular loops, an amino-terminus and a cytoplasmic carboxy-terminus. The loops have functional sites, including two cysteines amino acids for a disulfide bridge, Asp-Arg-Tyr, which is responsible for association with arrestin and, Lys/Arg-Lys/Arg-X-X-Lys/Arg, which interacts with G-proteins.The tachykinin receptor 1 can be found in both the central and peripheral nervous system. It is present in neurons, brainstem, vascular endothelial cells, muscle, gastrointestinal tracts, genitourinary tract, pulmonary tissue, thyroid gland and different types of immune cells. The binding of SP to the tachykinin receptor 1 has been associated with the transmission of stress signals and pain, the contraction of smooth muscles and inflammation. Tachykinin receptor 1 antagonists have also been studied in migraine, emesis and psychiatric disorders. In fact, aprepitant has been proved effective in a number of pathophysiological models of anxiety and depression. Other diseases in which the tachykinin receptor 1 system is involved include asthma, rheumatoid arthritis and gastrointestinal disorders.

Synonyms: neurokinin 1 antibody|NK 1 receptor antibody|NK 1R antibody|NK-1 receptor antibody|NK-1R antibody|NK1 receptor antibody|NK1R antibody|NK1R_HUMAN antibody|NKIR antibody|SPR antibody|Substance P receptor antibody|Substance-P receptor antibody|TAC 1R antibody|TAC1R antibody|Tachykinin 1 receptor(substance P receptor neurokinin 1 receptor) antibody|Tachykinin receptor 1 antibody|Tachykinin receptor 1(substance P receptor neurokinin 1 receptor) antibody|TACR1 antibody

UniProt: P25103

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration