HSD17B4 anticorps (C-Term)

N° du produit ABIN3044284

Cet anticorps Lapin Polyclonal détecte spécifiquement HSD17B4 dans WB et IHC. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour HSD17B4 anticorps (C-Term) (ABIN3044284)

Antigène: HSD17B4 (Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSD17B4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-HSD17B4 anticorps

Épitope: AA 744-761, C-Term

Fonction: Anti-Hydroxysteroid (17-beta) Dehydrogenase 4/HSD17B4 Antibody Picoband®

Séquence: NIMLSQKLQM ILKDYAKL

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-Hydroxysteroid (17-beta) Dehydrogenase 4/HSD17B4 Antibody (ABIN3044284). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of Hydroxysteroid(17-beta) Dehydrogenase 4, identical to the related rat and mouse sequences.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. "Entrez Gene: HSD17B4 Hydroxysteroid (17-beta) dehydrogenase 1". 2. Aka JA, Mazumdar M, Chen CQ, Poirier D, Lin SX (Apr 2010). "17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production".Molecular Endocrinology. 24 (4): 832-45.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur HSD17B4

Antigène: HSD17B4 (Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4))

Autre désignation: HSD17B4

Sujet:

Synonyms: Peroxisomal multifunctional enzyme type 2,MFE-2,17-beta-hydroxysteroid dehydrogenase 4,17-beta-HSD 4,D-bifunctional protein,DBP,Multifunctional protein 2,MPF-2,Short chain dehydrogenase/reductase family 8C member 1, (3R)-hydroxyacyl-CoA dehydrogenase,1.1.1.n12,Enoyl-CoA hydratase 2,4.2.1.107,4.2.1.119,3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase,HSD17B4,EDH17B4, SDR8C1,

Tissue Specificity: Present in many tissues with highest concentrations in liver, heart, prostate and testis.

Background: Peroxisomal multifunctional enzyme type 2 is a protein that in humans is encoded by the HSD17B4 gene. The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Sequence Similarities: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Poids moléculaire: 80 kDa

Pathways: Monocarboxylic Acid Catabolic Process