IFITM1 anticorps (N-Term)

N° du produit ABIN3044336

Détail du produit anti-IFITM1 anticorps

Antigène: IFITM1 (Interferon-Induced Transmembrane Protein 1 (IFITM1))

Épitope: AA 1-17, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IFITM1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Fonction: Rabbit IgG polyclonal antibody for Interferon-induced transmembrane protein 1(IFITM1) detection. Tested with WB, IHC-P, IHC-F in Human.

Séquence: MHKEEHEVAV LGPPPST

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Interferon-induced transmembrane protein 1(IFITM1) detection. Tested with WB, IHC-P, IHC-F in Human.
Gene Name: interferon induced transmembrane protein 1
Protein Name: Interferon-induced transmembrane protein 1

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human IFITM1(1-17aa MHKEEHEVAVLGPPPST).

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
IHC-F: Concentration: 0.5-1 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-IFITM1 (ABIN3044336)

Ma, Zhang, Fu, Xia, Zhan, Li, Wang, Wu: "Wnt signaling may be activated in a subset of Peutz-Jeghers syndrome polyps closely correlating to LKB1 expression." dans: Oncology reports, Vol. 23, Issue 6, pp. 1569-76, (2010) (PubMed).

Xu, Yang, Hu: "Binding of IFITM1 enhances the inhibiting effect of caveolin-1 on ERK activation." dans: Acta biochimica et biophysica Sinica, Vol. 41, Issue 6, pp. 488-94, (2009) (PubMed).

Yang, Xu, Chen, Hu: "IFITM1 plays an essential role in the antiproliferative action of interferon-gamma." dans: Oncogene, Vol. 26, Issue 4, pp. 594-603, (2007) (PubMed).

Détails sur IFITM1

Antigène: IFITM1 (Interferon-Induced Transmembrane Protein 1 (IFITM1))

Autre désignation: IFITM1 (IFITM1 Produits)

Synonymes: anticorps 9-27, anticorps CD225, anticorps DSPA2a, anticorps IFI17, anticorps LEU13, anticorps 1110036C17Rik, anticorps Mil-2, anticorps Mil2, anticorps interferon induced transmembrane protein 1, anticorps interferon induced transmembrane protein 1 (9-27), anticorps Ifitm1, anticorps IFITM1

Sujet: Interferon-induced Transmembrane Protein 1(IFITM1), also called Interferon-induced Protein 17(IFI17). IFITM1 activity is required for primordial germ cells(PGCs) transit from the mesoderm into the endoderm, and that it appears to act via a repulsive mechanism, such that PGCs avoid Ifitm1-expressing tissues. It is mapped to Chr.11 and belongs to the family of interferon-induced transmembrane proteins(Ifitm/mil/fragilis), which encodes cell surface proteins that may modulate cell adhesion and influence cell differentiation. Interferon-inducible membrane proteins of approximately 17 kDa have been suggested to play a role in the antiproliferative activity of interferons based on their pattern of induction in interferon-sensitive and -resistant cell lines and the ability of a membrane fraction enriched in 17- kDa proteins to inhibit cell growth.

Synonyms: 9-27 antibody|CD 225 antibody|CD 225 antigen antibody|CD225 antibody|CD225 antigen antibody|Dispanin subfamily A member 2a antibody|DSPA2a antibody|IFI 17 antibody|IFI17 antibody|IFITM1 antibody|IFM1_HUMAN antibody|Interferon induced protein 17 antibody|interferon induced transmembrane protein 1(9-27) antibody|Interferon induced transmembrane protein 1 antibody|Interferon inducible protein 9-27 antibody|Interferon-induced protein 17 antibody|Interferon-induced transmembrane protein 1 antibody|Interferon-inducible protein 9-27 antibody|Leu 13 antibody|Leu 13 antigen antibody|Leu-13 antigen antibody|LEU13 antibody

UniProt: P13164