PROC anticorps (C-Term)

N° du produit ABIN3044486

L’anticorps Lapin Polyclonal anti-PROC a été validé pour WB, IHC, ICC et FACS. Il convient pour détecter PROC dans des échantillons de Humain. Il y a 10+ publications disponibles.

Aperçu rapide pour PROC anticorps (C-Term) (ABIN3044486)

Antigène: PROC (Vitamin K-dependent protein C (PROC))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PROC est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Détail du produit anti-PROC anticorps

Épitope: AA 446-461, C-Term

Fonction: Anti-Protein C/PROC Antibody Picoband®

Séquence: HGHIRDKEAP QKSWAP

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-Protein C/PROC Antibody (ABIN3044486). Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human Protein C.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Human
Immunocytochemistry, 0.5-1 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human1. Allaart, C. F., Poort, S. R., Rosendaal, F. R., Reitsma, P. H., Bertina, R. M., Briet, E. Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect. Lancet 341: 134-138, 1993. 2. Beckmann, R. J., Schmidt, R. J., Santerre, R. F., Plutzky, J., Crabtree, G. R., Long, G. L. The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAs. Nucleic Acids Res. 13: 5233-5247, 1985. 3. Berg, L.-P., Scopes, D. A., Alhaq, A., Kakkar, V. V., Cooper, D. N. Disruption of a binding site for hepatocyte nuclear factor 1 in the protein C gene promoter is associated with hereditary thrombophilia. Hum. Molec. Genet. 3: 2147-2152, 1994.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-PROC (ABIN3044486)

Liu, An, Liu, Li, Tang, Chen: "Mouse lung slices: An ex vivo model for the evaluation of antiviral and anti-inflammatory agents against influenza viruses." dans: Antiviral research, Vol. 120, pp. 101-11, (2015) (PubMed).

Li, Wang, Zhao, Yang, Li, Zhao, Yu, Wang, Meng, Liu, Zhu, Gao, Jia, Yang: "Nuclear factor of activated T cells 5 maintained by Hotair suppression of miR-568 upregulates S100 calcium binding protein A4 to promote breast cancer metastasis." dans: Breast cancer research : BCR, Vol. 16, Issue 5, pp. 454, (2015) (PubMed).

Ban, Fan, Huang, Li, Chen, Zhang, Xu: "Mono-(2-ethylhexyl) phthalate induces injury in human umbilical vein endothelial cells." dans: PLoS ONE, Vol. 9, Issue 5, pp. e97607, (2014) (PubMed).

Tang, Li, Yu, Gao, Liu, Chen, Xing, Liu, Yao: "Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway." dans: The Journal of nutritional biochemistry, Vol. 25, Issue 6, pp. 675-82, (2014) (PubMed).

Zhang, Zhang, Goldstein, Li, Ge, He, Ruiz: "The effect of c-fos on acute myocardial infarction and the significance of metoprolol intervention in a rat model." dans: Cell biochemistry and biophysics, Vol. 65, Issue 2, pp. 249-55, (2013) (PubMed).

Aksu, Baykara, Kiray, Gurpinar, Sisman, Ekerbicer, Tas, Gokdemir-Yazar, Uysal: "Serum IGF-1 levels correlate negatively to liver damage in diabetic rats." dans: Biotechnic & histochemistry : official publication of the Biological Stain Commission, Vol. 88, Issue 3-4, pp. 194-201, (2013) (PubMed).

Chen, Liu, Yang, Leng: "Characterization of bmp15 and its regulation by human chorionic gonadotropin in the follicle of gibel carp (Carassius auratus gibelio)." dans: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, Vol. 163, Issue 1, pp. 121-8, (2012) (PubMed).

Yang, Gu, Zheng, Li, Lian, Miao, Jiang, Wei: "RPB5-mediating protein is required for the proliferation of hepatocellular carcinoma cells." dans: The Journal of biological chemistry, Vol. 286, Issue 13, pp. 11865-74, (2011) (PubMed).

Bao, Liu, Qin, Xu, Hei, Jaber, Chen: "An immunohistochemical study of S-100 protein in the intestinal tract of Chinese soft-shelled turtle, Pelodiscus sinensis." dans: Research in veterinary science, Vol. 91, Issue 3, pp. e16-24, (2011) (PubMed).

Zhang, He, Goldstein, Ge, Wang, Ruiz: "The expression and significance of proto-oncogene c-fos in viral myocarditis." dans: Virology journal, Vol. 7, pp. 285, (2010) (PubMed).

Détails sur PROC

Antigène: PROC (Vitamin K-dependent protein C (PROC))

Autre désignation: PROC

Sujet:

Synonyms: Vitamin K-dependent protein C,3.4.21.69,Anticoagulant protein C,Autoprothrombin IIA,Blood coagulation factor XIV,Vitamin K-dependent protein C light chain,Vitamin K-dependent protein C heavy chain,Activation peptide,PROC,

Tissue Specificity: Plasma, synthesized in the liver.

Background: Protein C (PROC), also called PC, is a zymogenic (inactive) protein, the activated form of which plays an important role in regulating blood clotting, inflammation, cell death and maintaining the permeability of blood vessel walls in humans and other animals. The PROC gene is mapped on 2q14.3. The PROC gene contains 8 exons and spans about 11 kb by Foster et al. The conversion of protein C to a protease with anticoagulant function by thrombin requires as a cofactor thrombomodulin, an endothelial cell membrane protein. Riewald et al. demonstrated that activated protein C uses the endothelial cell protein C receptor as a coreceptor for cleavage of protease-activated receptor-1 on endothelial cells. Faust et al. demonstrated that the endothelial pathways required for protein C activation are impaired in severe meningococcal sepsis. They stated that improvement in the outcome of children with meningococcal sepsis who were treated with unactivated protein C concentrates had been described in case reports and in 1 uncontrolled series.

Sequence Similarities: Belongs to the peptidase S1 family.

Poids moléculaire: 36 kDa

UniProt: P04070