Cathepsin K anticorps (AA 115-329)
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- Antigène Voir toutes Cathepsin K (CTSK) Anticorps
- Cathepsin K (CTSK)
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Épitope
- AA 115-329
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Cathepsin K est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Fonction
- Rabbit IgG polyclonal antibody for Cathepsin K(CTSK) detection. Tested with WB, IHC-P in Human.
- Réactivité croisée (Details)
- No cross reactivity with other proteins.
- Attributs du produit
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Rabbit IgG polyclonal antibody for Cathepsin K(CTSK) detection. Tested with WB, IHC-P in Human.
Gene Name: cathepsin K
Protein Name: Cathepsin K - Purification
- Immunogen affinity purified.
- Immunogène
- E. coli-derived human Cathepsin K recombinant protein (Position: A115-M329). Human Cathepsin K shares 86.9% and 88.8% amino acid (aa) sequence identity with mouse and rat Cathepsin K, respectively.
- Isotype
- IgG
- Top Product
- Discover our top product CTSK Anticorps primaire
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- Indications d'application
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users. - Commentaires
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Concentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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- Antigène
- Cathepsin K (CTSK)
- Autre désignation
- CTSK (CTSK Produits)
- Synonymes
- anticorps CTS02, anticorps CTSO, anticorps CTSO1, anticorps CTSO2, anticorps PKND, anticorps PYCD, anticorps AI323530, anticorps MMS10-Q, anticorps Ms10q, anticorps catK, anticorps CTSK, anticorps wu:fa95f03, anticorps wu:fb08b05, anticorps zgc:110367, anticorps cts02, anticorps ctso, anticorps ctso1, anticorps ctso2, anticorps pknd, anticorps pycd, anticorps OC-2, anticorps catk, anticorps cathepsin K, anticorps cathepsin K L homeolog, anticorps Cathepsin K, anticorps CTSK, anticorps Ctsk, anticorps ctsk, anticorps ctsk.L, anticorps catk
- Sujet
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Cathepsin K, abbreviated CTSK, is an enzyme that in humans is encoded by the CTSK gene. It is mapped to 1q21. The protein encoded by this gene is a lysosomal cysteine protease involved in bone remodeling and resorption. And this protein, which is a member of the peptidase C1 protein family, is expressed predominantly in osteoclasts. Additionally, the enzyme's ability to catabolize elastin, collagen, and gelatin allow it to break down bone and cartilage. This catabolic activity is also partially responsible for the loss of lung elasticity and recoil inemphysema. Cathepsin K inhibitors, such as odanacatib, show great potential in the treatment of osteoporosis. Cathepsin K is degraded by Cathepsin S, called Controlled Cathepsin Cannibalism.
Synonyms: Cathepsin K antibody|Cathepsin O antibody|Cathepsin O1 antibody|Cathepsin O2 antibody|Cathepsin X antibody|CATK_HUMAN antibody|CTS02 antibody|Ctsk antibody|CTSO antibody|CTSO1 antibody|CTSO2 antibody|MGC23107 antibody|PKND antibody|PYCD antibody - ID gène
- 1513
- UniProt
- P43235
- Pathways
- Activation of Innate immune Response, Toll-Like Receptors Cascades
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