Cathepsin K anticorps (AA 115-329)

N° du produit ABIN3044511

Cet anticorps anti-Cathepsin K Polyclonal Lapin (ABIN3044511) détecte spécifiquement Cathepsin K dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Cathepsin K anticorps (AA 115-329) (ABIN3044511)

Antigène: Cathepsin K (CTSK)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cathepsin K est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Cathepsin K anticorps

Épitope: AA 115-329

Fonction: Anti-Cathepsin K/CTSK Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Cathepsin K/CTSK Antibody (ABIN3044511). Tested in IHC, WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human Cathepsin K recombinant protein (Position: A115-M329). Human Cathepsin K shares 86.9% and 88.8% amino acid (aa) sequence identity with mouse and rat Cathepsin K, respectively.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur Cathepsin K

Antigène: Cathepsin K (CTSK)

Autre désignation: CTSK

Sujet:

Synonyms: Cathepsin K,3.4.22.38,Cathepsin O,Cathepsin O2,Cathepsin X,CTSK,CTSO, CTSO2,

Tissue Specificity: Predominantly expressed in osteoclasts (bones).

Background: Cathepsin K, abbreviated?CTSK, is an?enzyme?that in humans is encoded by the?CTSK?gene. It is mapped to 1q21. The protein encoded by this gene is a lysosomal?cysteine protease?involved in bone remodeling and resorption. And this protein, which is a member of the peptidase C1 protein family, is expressed predominantly in?osteoclasts. Additionally, the enzyme's ability to catabolize?elastin,?collagen, and?gelatin?allow it to break down?bone?and cartilage. This catabolic activity is also partially responsible for the loss of lung elasticity and recoil inemphysema. Cathepsin K?inhibitors, such as?odanacatib, show great potential in the treatment of?osteoporosis. Cathepsin K is degraded by Cathepsin S, called Controlled Cathepsin Cannibalism.

Poids moléculaire: 45 kDa

ID gène: 1513

UniProt: P43235

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades