SKAP1 anticorps (Middle Region)

N° du produit ABIN3044545

Cet anticorps Lapin Polyclonal détecte spécifiquement SKAP1 dans WB et IHC. Il présente une réactivité envers Humain et Rat.

Aperçu rapide pour SKAP1 anticorps (Middle Region) (ABIN3044545)

Antigène: SKAP1 (Src Kinase Associated phosphoprotein 1 (SKAP1))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SKAP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-SKAP1 anticorps

Épitope: AA 163-189, Middle Region

Fonction: Anti-SKAP55/SKAP1 Antibody Picoband®

Séquence: RMAPHLRRDS KKESCFELTS QDRRSYE

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-SKAP55/SKAP1 Antibody Picoband® (ABIN3044545). Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human SKAP55, different from the related mouse and rat sequences by two amino acids.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Rat, Human
Western blot, 0.1-0.5 μg/mL, Human
1. "Entrez Gene: SKAP1 src kinase associated phosphoprotein 1". 2. Marie-Cardine A, Bruyns E, Eckerskorn C, Kirchgessner H, Meuer SC, Schraven B (July 1997). "Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes". J Biol Chem 272 (26): 16077-80. 3. Wang H, Moon EY, Azouz A, et al. (2003). "SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates". Nat. Immunol. 4 (4): 366-74.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur SKAP1

Antigène: SKAP1 (Src Kinase Associated phosphoprotein 1 (SKAP1))

Autre désignation: SKAP1

Sujet:

Synonyms: Src kinase-associated phosphoprotein 1,Src family-associated phosphoprotein 1,Src kinase-associated phosphoprotein of 55 kDa,SKAP-55,pp55,SKAP1,SCAP1, SKAP55,

Tissue Specificity: Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level). .

Background: Src kinase-associated phosphoprotein 1 is an adapter protein that in humans is encoded by the SKAP1 gene. This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.

Poids moléculaire: 60 kDa

ID gène: 8631