TARDBP anticorps (AA 1-260)

N° du produit ABIN306465

Cet anticorps anti-TARDBP Monoclonal Souris (Clone k1B8) (ABIN306465) détecte spécifiquement TARDBP dans WB, IHC, ELISA et FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour TARDBP anticorps (AA 1-260) (ABIN306465)

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TARDBP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Clone: K1B8

Détail du produit anti-TARDBP anticorps

Épitope: AA 1-260

Fonction: Human TDP-43/TARDBP antibody

Purification: Purified

Immunogène: Recombinant human TARDBP (1-260aa) purified from E. coli

Isotype: IgG1 kappa

Information d'application

Indications d'application: Recommended dilution 1:1000(W.B), Recommended dilution 1:100(IHC)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing cycles

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Détails sur TARDBP

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Autre désignation: TDP-43/TARDBP

Sujet: TAR DNA binding protein (TARDBP), also known as TDP-43, is a cellular protein. TARDBP was identified as the disease accumulating protein in patients with frontotemporal lobar degeneration (FTLD) with ubiquitin inclusions (FTLD-U) and in amyotrophic lateral sclerosis (ALS). TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. In addition, this protein regulates alternate splicing of the cystic fibrosis transmembrane receptor (CFTR) gene.

NCBI Accession: NP_031401

Pathways: Positive Regulation of Peptide Hormone Secretion