LPAR1 anticorps (C-Term)

N° du produit ABIN306575

L’anticorps anti-LPAR1 Polyclonal Lapin est utilisé pour la détection de LPAR1 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour LPAR1 anticorps (C-Term) (ABIN306575)

Antigène: LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LPAR1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-LPAR1 anticorps

Épitope: C-Term

Fonction: Rabbit anti Human Lysophosphatidic Acid Receptor 1 CT (EDG-2)

Attributs du produit: Endothelial cell differentiation gene-2 (EDG-2) receptor is a high affinity receptor for lysophosphatidic acid (LPA). EDG-2, also known as lysophospholipid receptor A1, Vzg-1, mrec1.3 or GPCR26, like all other EDG receptors, couple multiple (3 or more) types of G proteins and transduce decreases in c[AMP]i through Gi and increases in [Ca2+]i by augmenting phospholipase C through Gq/11 and beta/gamma dimers and by induction of PI3 kinase, p125 FAK, phospholipase D by activating rho through G12/13. Human EDG-2 is present in high levels on oligodendrocytes and certain human malignant T cell lines. EDG-2 receptors (with EDG-4) may play a role in protecting cardiomyocytes from apoptosis induced by hypoxia and andrenergic stimulation.

Purification: Ammonium Sulfate Precipitation

Immunogène: Synthetic peptide derived from the C terminal of the EDG2 receptor.

Isotype: IgG

Information d'application

Indications d'application: For Western blotting, starting dilution of 5-10 μg/mL is recommended. Western blot should be visualized using a high sensitivity secondary/substrate system (i.e. Pierce's SuperSignal West Femto Maximum Sensitivity Substrate). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/ml

Buffer: phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur LPAR1

Antigène: LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))

Autre désignation: Lysophosphatidic Acid Receptor 1 CT (EDG-2)

Sujet: Endothelial Cell Differentiation Gene Receptor 2, Lysophosphatidic Acid Receptor 1

UniProt: Q92633

Pathways: Myometrial Relaxation and Contraction, Smooth Muscle Cell Migration