Cet anticorps Mouton Polyclonal détecte spécifiquement Epstein-Barr Virus Nuclear Antigen-3A dans ELISA, IHC (fro), IHC (p), DB, ICC et WB. Il présente une réactivité avec des échantillons de Virus.
EBNA-3A is a latent viral nuclear protein expressed in EBV transformed lymphoblastic cell lines. It is also found in some immunoblastic lymphomas in vivo. This viral nuclear protein is essential for EBV mediated transformation of B lymphocytes. The EBNA-3A functions as a transcriptional regulator though the target genes are currently unknown. Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop
EBNA-3A
Reactivité: Epstein-Barr Virus (EBV)
ELISA, IHC (fro), IHC (p), IF (cc), IF (p)
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Western blotting at 0.25-1.00 μg/mL, Dot blotting, ELISA, Immunocytochemistry and Immunohistochemistry on frozen and paraffin embedded tissues. Optimal concentrations must be determined by titration.
Restrictions
For Research Use only
Format
Liquid
Buffer
phosphate buffered saline with 0.08 % sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C
Stockage commentaire
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles