PPP4R1 anticorps (AA 38-52)

N° du produit ABIN306662

L’anticorps anti-PPP4R1 Polyclonal Lapin est utilisé pour la détection de PPP4R1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB.

Aperçu rapide pour PPP4R1 anticorps (AA 38-52) (ABIN306662)

Antigène: PPP4R1 (Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPP4R1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PPP4R1 anticorps

Épitope: AA 38-52

Fonction: Rabbit anti Human Protein Phosphatase 4 R1 (X/A'2)

Attributs du produit: Protein serine/threonine phosphatase 4R1 is a protein which is associated with the catalytic subunit of protein serine/threonine phosphatase 4 (PP4C) and may possibly regulate the activity of the enzyme. PP4C is 65 % identical to PP2AC at the amino acid level and has been placed in the type 2A family of phosphatases. PP4C has been highly conserved between species sharing 91 % amino acid identity between human and Drosophila PP4C is predominantly localized in the nucleus in rat brain and liver but is most highly expressed in testis. Additionally, PP4C was demonstrated to be an essential enzyme in the development of Drosophila embryos. The expression of PP4C was reduced to 25 % of the normal protein level in a mutant strain of Drosophila termed centrosomes minus microtubules (cmm). An interesting characteristic of the cmm phenotype is the presence of regions of cells that are unable to complete mitosis because no microtubules exist to connect chromatin and centrosomes. This phenotype implicates PP4C in the regulation of the nucleation and/or stabilization of microtubules. These data taken together indicate that PP4 has a crucial cellular function, although a physiological substrate for PP4 has not yet been identified.

Purification: Ammonium Sulfate Precipitation

Immunogène: Antibody raised against synthetic peptide corresponding to amino acids 38 to 52 of the human protein phosphatase 4R1.

Isotype: IgG

Information d'application

Indications d'application: Detects protein phosphatase X/A (PP4 R1) protein by Western blot. Detects a 125 kDa band in bovine testes lysate. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur PPP4R1

Antigène: PPP4R1 (Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1))

Autre désignation: Protein Phosphatase 4 R1 (X/A'2)

Sujet: Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 1, Protein Phosphatase X/A'2, PP4R1

UniProt: Q8TF05, Q8K2V1, Q8VI02