LEF-1 Transactivation Domain anticorps

N° du produit ABIN306723

Cet anticorps anti-LEF-1 Transactivation Domain Monoclonal Souris (Clone 3A12) (ABIN306723) détecte spécifiquement LEF-1 Transactivation Domain dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour LEF-1 Transactivation Domain anticorps (ABIN306723)

Antigène: LEF-1 Transactivation Domain

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Application: Western Blotting (WB)

Clone: 3A12

Détail du produit

Fonction: Mouse anti Human LEF-1 transactivation domain

Réactivité croisée: Humain

Attributs du produit: Lymphoid Enhancer Factor-1 (LEF-1) is an HMG 1/2-like DNA binding/bending protein and is a member of the LEF/TCF transcription factor family. There are four LEF/TCF family members in mammalian systems (LEF-1, TCF-1, TCF-3 and TCF-4), and orthologs to these factors have been identified in many different species. LEF/TCFs are downstream mediators of Wnt/Wingless signals. Wnt signaling drives cell polarity, cell fate and cell growth decisions in embryonic tissues and in post-natal tissues that continue to develop from mitotically active stem cell precursors. Misregulation of Wnt signaling is also implicated as a root cause of many different cancers, such as colon cancer, melanoma, breast cancer, prostate cancer and others. This antibody recognizes an epitope in amino acids 236-242 of LEF-1. This region is found within the transactivation domain of LEF-1. However, it is not present in some splice variants.

Purification: Protein A/G Chromatography

Immunogène: .

Isotype: IgG1

Information d'application

Indications d'application: Antibody detects amino acids 236-242 of human LEF-1. Epitope is missing in some splice variants. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détail du antigène

Antigène: LEF-1 Transactivation Domain

Sujet: Anti-Lymphoid Enhancer Factor-1, Transactivation Domain (amino acids 236-242) Monoclonal Antibody

UniProt: Q9UJU2