LEF-1 Alternate Exon (full length) anticorps

N° du produit ABIN306724

Cet anticorps Souris Monoclonal détecte spécifiquement LEF-1 Alternate Exon dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour LEF-1 Alternate Exon (full length) anticorps (ABIN306724)

Antigène: LEF-1 Alternate Exon

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Application: Western Blotting (WB)

Clone: 1C3

Détail du produit

Épitope: full length

Fonction: Mouse anti Human LEF-1 alternate exon

Réactivité croisée: Humain

Attributs du produit: Lymphoid Enhancer Factor-1 (LEF-1) is an HMG 1/2-like DNA binding/bending protein and is a member of the LEF/TCF transcription factor family. There are four LEF/TCF family members in mammalian systems (LEF-1, TCF-1, TCF-3 and TCF-4), and orthologs to these factors have been identified in many different species. LEF/TCFs are downstream mediators of Wnt/Wingless signals. Wnt signaling drives cell polarity, cell fate and cell growth decisions in embryonic tissues and in post-natal tissues that continue to develop from mitotically active stem cell precursors. Misregulation of Wnt signaling is also implicated as a root cause of many different cancers, such as colon cancer, melanoma, breast cancer, prostate cancer and others. This antibody is specific for an epitope between a.a. 227-231. This sequence lies within the context dependent activation domain of LEF-1 and appears to be an alternate splice variant exon of the LEF-1 gene

Purification: Protein A/G Chromatography

Immunogène: Recombinant full-length LEF-1 protein

Isotype: IgG1

Information d'application

Indications d'application: Detect LEF-1 protein containing the alternately spliced exon between amino acids 212-241 by Western blot at 1-5 μg/mL. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détail du antigène

Antigène: LEF-1 Alternate Exon

Sujet: Mouse Anti Lef-1, Lymphoid Enhancer Factor 1

UniProt: Q9UJU2