S1PR1 anticorps (C-Term)

N° du produit ABIN306730

Cet anticorps Lapin Polyclonal détecte spécifiquement S1PR1 dans WB. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour S1PR1 anticorps (C-Term) (ABIN306730)

Antigène: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp S1PR1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-S1PR1 anticorps

Épitope: C-Term

Fonction: Rabbit anti Human Sphingosine 1 Phosphate Receptor 1 (EDG-1) CT

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: EDG-1 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-1 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-1 is expressed in cardiovascular, leukocyte- containing and other tissues.

Purification: Ammonium Sulfate Precipitation

Immunogène: Synthetic peptide derived from the C-terminal of the EDG-1 receptor

Isotype: IgG

Information d'application

Indications d'application: Detects EDG1 receptors at concentration of 5-10 μg/mL by Western blot using a human EDG1 receptor transfected cell line. Detects an approximately 44 kDa band in RH7777 cells transfected with full length human EDG1. Due to low expression of EDG receptors, we recommend use of Pierce Femto Signal substrate for western blot development. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur S1PR1

Antigène: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Autre désignation: Sphingosine 1 Phosphate Receptor 1 (EDG-1)

Sujet: Endothelial cell differentiation gene 1 C-terminal

UniProt: P21453

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2