S1PR4 anticorps

N° du produit ABIN306801

Cet anticorps anti-S1PR4 Polyclonal Lapin (ABIN306801) détecte spécifiquement S1PR4 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour S1PR4 anticorps (ABIN306801)

Antigène: S1PR4 (Sphingosine-1-Phosphate Receptor 4 (S1PR4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp S1PR4 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-S1PR4 anticorps

Fonction: Rabbit anti Human Sphingosine 1 Phosphate 4 Receptor (CT) (EDG6)

Réactivité croisée: Humain

Attributs du produit: EDG-6 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-6 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-6 is expressed in lymphoid and hematopoietic tissue and in the lungs. Recently, the designation of the EDG receptors has been modified to include the ligand for the receptor. Thus, the new designation for the EDG-6 receptor is the sphingosine 1-phosphate receptor-4 (S1P-4).

Purification: Ammonium Sulfate Precipitation

Information d'application

Indications d'application: Detects EDG6 receptors at concentration of 5-10 μg/mL by Western blot using a human EDG6 receptor transfected cell line. Detects an approximately 45 kDa band in Cos cells transfected with full length human EDG6. Due to low expression of EDG receptors, we recommend use of Pierce Femto Signal substrate for western blot development. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur S1PR4

Antigène: S1PR4 (Sphingosine-1-Phosphate Receptor 4 (S1PR4))

Autre désignation: Sphingosine 1 Phosphate 4 Receptor (CT) (EDG6)

Sujet: Endothelial cell differentiation gene 6 C-terminal, Sphingosine-1-Phosphate Receptor-4 (S1P-4)

UniProt: O95977