Fibronectin anticorps

N° du produit ABIN306829

Cet anticorps Souris Monoclonal détecte spécifiquement Fibronectin dans IHC (p) et IHC (fro). Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour Fibronectin anticorps (ABIN306829)

Antigène: Fibronectin

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Fibronectin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: EP5

Détail du produit anti-Fibronectin anticorps

Fonction: Mouse anti Human Fibronectin

Réactivité croisée: Humain, Souris

Attributs du produit: Fibronectins are a family of plasma and extracellular matrix glycoproteins that contain multiple sites for various ligands and cells. The region of fibronectin that mediates cell adhesion in a majority of cell types is in the carboxy terminal domain and involves the binding of the Arg-Gly-Asp (RGD) sequence to a specific polypeptide cell surface receptor. Although the mechanisms of fibronectin extracellular matrix assembly are not well understood, specific antibodies have been used to determine the domains involved in matrix assembly. This antibody stains the extracellular adhesive glycoprotein of fibronectin in connective tissues and vessels. It does not recognize the soluble dimeric form of fibronectin (plasma fibronectin) but strongly stains matrix fibronectin in tissues. Animal biodistribution experiments have shown that after intravenous administration, this antibody localizes to tumor vessels where it binds to the underlying basement membrane. The antigen is not accessible in normal tissues to circulating antibody indicating that this antibody can be used to target tumor vessels specifically in vivo.

Purification: Protein A/G Chromatography

Isotype: IgG1

Information d'application

Indications d'application: Antibody can be used for staining of human and mouse frozen and paraffin-embedded tissue sections. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur Fibronectin

Antigène: Fibronectin

Sujet: Fibronectin

UniProt: P02751