TYROBP anticorps (Cytoplasmic Domain)

N° du produit ABIN306916

Cet anticorps Lapin Polyclonal détecte spécifiquement TYROBP dans WB et IP. Il présente une réactivité envers Humain.

Aperçu rapide pour TYROBP anticorps (Cytoplasmic Domain) (ABIN306916)

Antigène: TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TYROBP est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-TYROBP anticorps

Épitope: Cytoplasmic Domain

Réactivité croisée: Humain, Souris

Attributs du produit: TYRO protein tyrosine kinase-binding protein, DNAX-activation protein 12, Killer-activating receptor-associated protein, KARAP, TYROBP,DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells (1,2). DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction (3). Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice (4,5), as well as presenile dementia and bone cysts in humans (6).

Purification: Ammonium Sulfate Precipitation

Immunogène: Rabbit immunized with recombinant DAP12 protein (cytoplasmic domain).

Information d'application

Indications d'application: Antibody can be used for immunoprecipitation (2-4 μg/mg of protein lysate). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur TYROBP

Antigène: TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Autre désignation: DAP12

UniProt: O43914