Nitrotyrosine anticorps

N° du produit ABIN306957

Cet anticorps anti-Nitrotyrosine Monoclonal Souris (Clone 2A12) (ABIN306957) détecte spécifiquement Nitrotyrosine dans WB.

Aperçu rapide pour Nitrotyrosine anticorps (ABIN306957)

Antigène: Nitrotyrosine

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Nitrotyrosine est non-conjugé

Application: Western Blotting (WB)

Clone: 2A12

Détail du produit anti-Nitrotyrosine anticorps

Fonction: Mouse anti Nitrotyrosine

Specificité: Nitrotyrosine

Attributs du produit: Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxide signaling. While multiple nonenzymatic mechanisms are known to be capable of producing nitrated tyrosine residues, most tyrosine nitration events involve catalysis by metalloproteins such as myeloperoxidase, eosinophilperoxidase, myoglobin, the cytochrome P-450s, superoxide dismutase and prostacyclin synthase. Various studies have shown that protein tyrosinenitration is limited to specific proteins and that the process is selective. For example, exposure of human surfactant protein A (SP-A) to oxygen-nitrogen intermediates generated by activated alveolar macrophages resulted in specific nitration of SP-A at tyrosines 164 and 166, while addition of 1.2 mMCO 2 resulted in additional nitration at tyrosine 161. The presence of nitrotyrosine-containing proteins has shown high correlation to disease states such as atherosclerosis, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis.

Immunogène: 3-Nitrotyrosine-KLH

Isotype: IgG1

Information d'application

Indications d'application: Antibody can be used for Western blotting (Suggested dilution - 1:1000) and immunohistochemistry. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur Nitrotyrosine

Antigène: Nitrotyrosine

Classe de substances: Chemical