Netrin 1 anticorps

N° du produit ABIN307033

Cet anticorps Lapin Polyclonal détecte spécifiquement Netrin 1 dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour Netrin 1 anticorps (ABIN307033)

Antigène: Netrin 1 (NTN1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Netrin 1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Netrin 1 anticorps

Réactivité croisée: Cat, Boeuf (Vache), Humain, Macaque, Souris, Rat

Attributs du produit: Netrin 1, NTN1,Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis. Netrin 1s main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity.

Purification: Ammonium Sulfate Precipitation

Immunogène: Synthetic peptide derived from the human Netrin 1 protein

Isotype: IgG

Information d'application

Indications d'application: Antibody can be used for Western blotting (0.5-2 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur Netrin 1

Antigène: Netrin 1 (NTN1)

Autre désignation: Netrin 1

NCBI Accession: NP_004813

Pathways: Regulation of Cell Size