CERS6 anticorps

N° du produit ABIN307137

Cet anticorps anti-CERS6 Polyclonal Lapin (ABIN307137) détecte spécifiquement CERS6 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour CERS6 anticorps (ABIN307137)

Antigène: CERS6 (Ceramide Synthase 6 (CERS6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CERS6 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CERS6 anticorps

Fonction: Rabbit anti Human Lass6

Réactivité croisée: Humain

Attributs du produit: Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family. Five mammalian homologs have been reported, and the corresponding proteins have previously been investigated with respect to their key role in ceramide synthesis. However, members of the LAG family have been shown to be involved in cell growth regulation and cancer differentiation. May be involved in sphingolipid synthesis or its regulation. Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Localized to nuclear membrane a multi-pass membrane protein, may be expressed on endoplasmic reticulum membrane. Glycosylation on Asn-18 is not necessary for function. Like other LAG family members, the LASS6 protein contained a homeodomain and LAG1 domain. Lass6 displays highest homology to LASS5. The corresponding gene was localized to human chromosome 2q24.3, spanning a rather large genomic region of 318 kb. Sequences in mouse and zebrafish suggested a conservation of LASS6 in vertebrates because the protein and corresponding genomic sequences are highly conserved. LASS6 was shown to be broadly expressed in a wide range of tissues. Recent data suggested a role in cancer differentiation and early embryonic development.

Purification: Ammonium Sulfate Precipitation

Immunogène: Synthetic peptide dervied from human Lass6 protein

Information d'application

Indications d'application: Antibody can be used for Western blotting (5-7 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur CERS6

Antigène: CERS6 (Ceramide Synthase 6 (CERS6))

Autre désignation: Lass6

Sujet: LAG1 longevity assurance homolog 6

UniProt: Q6ZMG9