G Protein-Coupled Receptor 119 anticorps

N° du produit ABIN317642

Détail du produit anti-G Protein-Coupled Receptor 119 anticorps

Antigène: G Protein-Coupled Receptor 119 (GPR119)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp G Protein-Coupled Receptor 119 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificité: This antibody detects endogenous levels of GPR119 protein.(region surrounding Val227)

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: ELISA: 1/1000-1/5000. Western Blot: 1/500-1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0,05 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur G Protein-Coupled Receptor 119

Antigène: G Protein-Coupled Receptor 119 (GPR119)

Autre désignation: GPR119 (GPR119 Produits)

Synonymes: anticorps GPR119, anticorps GPCR2, anticorps G protein-coupled receptor 119, anticorps G-protein coupled receptor 119, anticorps GPR119, anticorps gpr119, anticorps Gpr119

Sujet: G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intra cellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane- spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR119 is a 335 amino acid protein that is mainly expressed in the pancreas. It is an endogenous receptor for lysophosphatidylcholine (LPC), which is is a lipid mediator involved in insulin secretion from pancreatic cells. GPR119 may participate in this insulin secretion, suggesting that it may be potential target for new anti-diabetic drugs.Synonyms: G-protein coupled receptor 119, Glucose-dependent insulinotropic receptor

Poids moléculaire: approx. 37 kDa

ID gène: 139760

NCBI Accession: NP_848566

UniProt: Q8TDV5

Pathways: Hormone Transport, Peptide Hormone Metabolism