CRHR2 anticorps

N° du produit ABIN317648

Détail du produit anti-CRHR2 anticorps

Antigène: CRHR2 (Corticotropin Releasing Hormone Receptor 2 (CRHR2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRHR2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificité: This antibody detects endogenous levels of CRF-RII protein.(region surrounding His112)

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: ELISA: 1/10000-1/20000. Western Blot: 1/500-1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0,05 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CRHR2

Antigène: CRHR2 (Corticotropin Releasing Hormone Receptor 2 (CRHR2))

Autre désignation: CRHR2 (CRHR2 Produits)

Synonymes: anticorps CRF-RB, anticorps CRF2, anticorps CRFR2, anticorps HM-CRF, anticorps CRF-R2, anticorps CRFR2alpha, anticorps CRFR2beta, anticorps Crfr2, anticorps Crf2r, anticorps CRH-R2, anticorps crhr2-A, anticorps corticotropin releasing hormone receptor 2, anticorps corticotropin releasing hormone receptor 2 S homeolog, anticorps CRHR2, anticorps Crhr2, anticorps crhr2.S

Sujet: Individuals suffering from Alzheimer's disease (AD) exhibit dramatic reductions in the content of corticotropin-releasing factor (CRF), increased expression of CRF receptors (CRFRs) and abnormalities in neuronal morphology in affected brain areas. In addition, AD patients show decreased concentrations of CRF in their cerebrospinal fluid, which may contribute to their cognitive impairment. A high affinity CRF binding protein, designated CRF-BP, has been discovered in postmortem brain samples from AD patients. CRF-BP serves to bind and inactivate CRF, reducing the pool of ''free CRF'' available to bind CRFRs. Two CRF receptors, designated CRF-RI and CFR-RII, exhibit distinct brain localizations. Two forms of CFR-RII, designated CFR-RIIalpha and CFR-RIIbeta, result from alternative mRNA splicing. Urocortin, an additional member of the CRF family, shares 63 % sequence identity with urotensin and 45 % sequence identity with CRF. Urocortin specifically binds to and activates CRF-RI and CRF-RII, but binds to CRF-RII more efficiently than CRF, suggesting that it may be the true, high affinity ligand for the CRF receptor type II.Synonyms: CRF-R 2, CRF2, CRF2R, CRH2R, Corticotropin-releasing factor receptor 2, Corticotropin-releasing hormone receptor 2

ID gène: 1395

NCBI Accession: NP_001189404

UniProt: Q13324

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Feeding Behaviour