LPAR1 anticorps

N° du produit ABIN317688

Détail du produit anti-LPAR1 anticorps

Antigène: LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LPAR1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of EDG-2 protein.(region surrounding Trp45)

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: Western Blot: 1/500-1/1000. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur LPAR1

Antigène: LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))

Autre désignation: EDG-2 / LPAR1 (LPAR1 Produits)

Synonymes: anticorps EDG2, anticorps GPR26, anticorps Gpcr26, anticorps LPA1, anticorps Mrec1.3, anticorps VZG1, anticorps edg-2, anticorps rec.1.3, anticorps vzg-1, anticorps Edg2, anticorps EDG-2, anticorps 5031439C20, anticorps AI326300, anticorps Kdt2, anticorps lpA1, anticorps edg2, anticorps si:dz22b13.1, anticorps si:dz46m7.1, anticorps zgc:92157, anticorps LPA receptor 1-A, anticorps LPA-1-A, anticorps gpr26, anticorps lpa1, anticorps lpa1r, anticorps lpa1r1, anticorps lpar1, anticorps lpar1-a, anticorps lpar1-b, anticorps vzg1, anticorps xLPA1-1, anticorps LPA receptor 1-B, anticorps LPA-1-B, anticorps edg2-A, anticorps xLPA1-2, anticorps xlpa1R, anticorps lysophosphatidic acid receptor 1, anticorps lysophosphatidic acid receptor 1 S homeolog, anticorps lysophosphatidic acid receptor 1 L homeolog, anticorps LPAR1, anticorps Lpar1, anticorps lpar1, anticorps lpar1.S, anticorps lpar1.L

Sujet: The EDG (endothelial differentiation gene) family of G protein-coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high affinity. EDG-6 is a low affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. Expressed in lymphoid and hematopoietic tissues and in lung, EDG-6 signals through Gi/o proteins, which activate growth related pathways.Synonyms: EDG2, LPA receptor 1, LPA-1, LPA1, LPAR1, Lysophosphatidic acid receptor 1, Lysophosphatidic acid receptor Edg-2

Poids moléculaire: approx. 38 kDa

ID gène: 1902

NCBI Accession: NP_001392

UniProt: Q92633

Pathways: Myometrial Relaxation and Contraction, Smooth Muscle Cell Migration